Abstract
Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1548-1556 |
| Number of pages | 9 |
| Journal | CardioVascular and Interventional Radiology |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2015 |
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Keywords
- Cone-beam computed tomography
- Hepatocellular carcinoma
- Quantitative
- Three dimensional
- Transcatheter arterial chemoembolization
- Tumor response
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma. / Wang, Zhijun; Chen, Rongxin; Duran, Rafael; Zhao, Yan; Yenokyan, Gayane; Chapiro, Julius; Schernthaner, Rüdiger; Radaelli, Alessandro; Lin, MingDe D.; Geschwind, Jean François.
In: CardioVascular and Interventional Radiology, Vol. 38, No. 6, 01.12.2015, p. 1548-1556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
AU - Wang, Zhijun
AU - Chen, Rongxin
AU - Duran, Rafael
AU - Zhao, Yan
AU - Yenokyan, Gayane
AU - Chapiro, Julius
AU - Schernthaner, Rüdiger
AU - Radaelli, Alessandro
AU - Lin, MingDe D.
AU - Geschwind, Jean François
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p
AB - Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p
KW - Cone-beam computed tomography
KW - Hepatocellular carcinoma
KW - Quantitative
KW - Three dimensional
KW - Transcatheter arterial chemoembolization
KW - Tumor response
UR - http://www.scopus.com/inward/record.url?scp=84947485618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947485618&partnerID=8YFLogxK
U2 - 10.1007/s00270-015-1129-9
DO - 10.1007/s00270-015-1129-9
M3 - Article
C2 - 26001366
AN - SCOPUS:84947485618
VL - 38
SP - 1548
EP - 1556
JO - CardioVascular and Interventional Radiology
JF - CardioVascular and Interventional Radiology
SN - 7415-5101
IS - 6
ER -