Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

Zhijun Wang, Rongxin Chen, Rafael Duran, Yan Zhao, Gayane Yenokyan, Julius Chapiro, Rüdiger Schernthaner, Alessandro Radaelli, MingDe D. Lin, Jean François Geschwind

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p 

Original languageEnglish (US)
Pages (from-to)1548-1556
Number of pages9
JournalCardioVascular and Interventional Radiology
Volume38
Issue number6
DOIs
StatePublished - Dec 1 2015

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Ethiodized Oil
Cone-Beam Computed Tomography
Hepatocellular Carcinoma
Magnetic Resonance Imaging
Tumor Burden
Neoplasms
Linear Models
Necrosis
Research Ethics Committees
Students

Keywords

  • Cone-beam computed tomography
  • Hepatocellular carcinoma
  • Quantitative
  • Three dimensional
  • Transcatheter arterial chemoembolization
  • Tumor response

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma. / Wang, Zhijun; Chen, Rongxin; Duran, Rafael; Zhao, Yan; Yenokyan, Gayane; Chapiro, Julius; Schernthaner, Rüdiger; Radaelli, Alessandro; Lin, MingDe D.; Geschwind, Jean François.

In: CardioVascular and Interventional Radiology, Vol. 38, No. 6, 01.12.2015, p. 1548-1556.

Research output: Contribution to journalArticle

Wang, Zhijun ; Chen, Rongxin ; Duran, Rafael ; Zhao, Yan ; Yenokyan, Gayane ; Chapiro, Julius ; Schernthaner, Rüdiger ; Radaelli, Alessandro ; Lin, MingDe D. ; Geschwind, Jean François. / Intraprocedural 3D Quantification of Lipiodol Deposition on Cone-Beam CT Predicts Tumor Response After Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma. In: CardioVascular and Interventional Radiology. 2015 ; Vol. 38, No. 6. pp. 1548-1556.
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abstract = "Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p ",
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AU - Wang, Zhijun

AU - Chen, Rongxin

AU - Duran, Rafael

AU - Zhao, Yan

AU - Yenokyan, Gayane

AU - Chapiro, Julius

AU - Schernthaner, Rüdiger

AU - Radaelli, Alessandro

AU - Lin, MingDe D.

AU - Geschwind, Jean François

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N2 - Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p 

AB - Purpose: To evaluate whether intraprocedural 3D quantification of Lipiodol deposition on cone-beam computed tomography (CBCT) can predict tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). Materials and Methods: This IRB approved, retrospective analysis included 36 patients with 51 HCC target lesions, who underwent cTACE with CBCT. CE-MRI was acquired at baseline and 1 month after cTACE. Overall tumor volumes as well as intratumoral Lipiodol volumes on CBCT were measured and compared with the overall and necrotic (non-enhancing) tumor volumes on CE-MRI using the paired student’s t test. Tumor response on CE-MRI was assessed using modified response evaluation criteria in solid tumors (mRECIST). A linear regression model was used to correlate tumor volumes, Lipiodol volumes, and the percentage of Lipiodol deposition on CBCT with the corresponding parameters on CE-MRI. Nonparametric spearman rank-order correlation and trend test were used to correlate the percentage of Lipiodol deposition in the tumor with tumor response. Result: A strong correlation between overall tumor volumes on CBCT and CE-MRI was observed (R2 = 0.986). In addition, a strong correlation was obtained between the volume of Lipiodol deposition on CBCT and tumor necrosis (in cm3) on CE-MRI (R2 = 0.960), and between the percentage of Lipiodol deposition and tumor necrosis (R2 = 0.979). Importantly, the extent of Lipiodol deposition (in percentage of total tumor volume) correlated strongly with tumor response on CE-MRI (Spearman rho = 0.84, p 

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