Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model

Ming Yang, Tao Yu, Joseph Wood, Ying Ying Wang, Benjamin C. Tang, Qi Zeng, Brian W. Simons, Jie Fu, Chi Mu Chuang, Samuel K. Lai, T. C. Wu, Chien Fu Hung, Justin Hanes

Research output: Contribution to journalArticlepeer-review

Abstract

Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalDrug Delivery and Translational Research
Volume4
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Biodegradable polymers
  • Chemotherapy
  • Controlled release
  • Drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

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