Intraoperative cerebral glioma characterization with contrast enhanced ultrasound

Francesco Prada, Luca Mattei, Massimiliano Del Bene, Luca Aiani, Marco Saini, Cecilia Casali, Assunta Filippini, Federico Giuseppe Legnani, Alessandro Perin, Andrea Saladino, Ignazio Gaspare Vetrano, Luigi Solbiati, Alberto Martegani, Francesco Dimeco

Research output: Contribution to journalArticle

Abstract

Background. Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before. Aim. To perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas. Methods. We performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma. An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging. A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria. Results were related to histopathology. Results. We observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase. HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns. Conclusion. Our study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors' biology. CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.

Original languageEnglish (US)
Article number484261
JournalBioMed Research International
Volume2014
DOIs
StatePublished - 2014

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Glioma
Ultrasonics
Tumors
Surgery
Brain
Refining
Labels
Brain Neoplasms
Visualization
Neoplasms
Imaging techniques
Perfusion
Economics

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Prada, F., Mattei, L., Del Bene, M., Aiani, L., Saini, M., Casali, C., ... Dimeco, F. (2014). Intraoperative cerebral glioma characterization with contrast enhanced ultrasound. BioMed Research International, 2014, [484261]. https://doi.org/10.1155/2014/484261

Intraoperative cerebral glioma characterization with contrast enhanced ultrasound. / Prada, Francesco; Mattei, Luca; Del Bene, Massimiliano; Aiani, Luca; Saini, Marco; Casali, Cecilia; Filippini, Assunta; Legnani, Federico Giuseppe; Perin, Alessandro; Saladino, Andrea; Vetrano, Ignazio Gaspare; Solbiati, Luigi; Martegani, Alberto; Dimeco, Francesco.

In: BioMed Research International, Vol. 2014, 484261, 2014.

Research output: Contribution to journalArticle

Prada, F, Mattei, L, Del Bene, M, Aiani, L, Saini, M, Casali, C, Filippini, A, Legnani, FG, Perin, A, Saladino, A, Vetrano, IG, Solbiati, L, Martegani, A & Dimeco, F 2014, 'Intraoperative cerebral glioma characterization with contrast enhanced ultrasound', BioMed Research International, vol. 2014, 484261. https://doi.org/10.1155/2014/484261
Prada, Francesco ; Mattei, Luca ; Del Bene, Massimiliano ; Aiani, Luca ; Saini, Marco ; Casali, Cecilia ; Filippini, Assunta ; Legnani, Federico Giuseppe ; Perin, Alessandro ; Saladino, Andrea ; Vetrano, Ignazio Gaspare ; Solbiati, Luigi ; Martegani, Alberto ; Dimeco, Francesco. / Intraoperative cerebral glioma characterization with contrast enhanced ultrasound. In: BioMed Research International. 2014 ; Vol. 2014.
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AU - Casali, Cecilia

AU - Filippini, Assunta

AU - Legnani, Federico Giuseppe

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AU - Dimeco, Francesco

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