Intraocular Schwannoma

Jae Young You; Paul T. Finger; Codrin Iacob; Steven A. McCormick; Tatyana Milman

doi:10.1016/j.survophthal.2012.04.003

Intraocular Schwannoma

Jae Young You, Paul T. Finger, Codrin Iacob, Steven A. McCormick, Tatyana Milman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a " pseudomelanoma" , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

Original language	English (US)
Pages (from-to)	77-85
Number of pages	9
Journal	Survey of ophthalmology
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/j.survophthal.2012.04.003
State	Published - Jan 2013

Keywords

Benign nerve sheath tumor
Choroidal neurilemmoma
Choroidal schwannoma
Intraocular neurilemmoma
Intraocular schwannoma
Pseudomelanoma
Uveal neurilemmoma
Uveal schwannoma

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/j.survophthal.2012.04.003

Cite this

@article{717d2738e0354ea186448332dc3cc783,

title = "Intraocular Schwannoma",

abstract = "Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a {"} pseudomelanoma{"} , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.",

keywords = "Benign nerve sheath tumor, Choroidal neurilemmoma, Choroidal schwannoma, Intraocular neurilemmoma, Intraocular schwannoma, Pseudomelanoma, Uveal neurilemmoma, Uveal schwannoma",

author = "You, {Jae Young} and Finger, {Paul T.} and Codrin Iacob and McCormick, {Steven A.} and Tatyana Milman",

note = "Funding Information: The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this article. Publication of this article was supported (in part) by The Eye Cancer Foundation, Inc. ( http://eyecancerfoundation.net ) and the Ophthalmic Pathology Research Fund. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

year = "2013",

month = jan,

doi = "10.1016/j.survophthal.2012.04.003",

language = "English (US)",

volume = "58",

pages = "77--85",

journal = "Survey of ophthalmology",

issn = "0039-6257",

publisher = "Elsevier USA",

number = "1",

}

TY - JOUR

T1 - Intraocular Schwannoma

AU - You, Jae Young

AU - Finger, Paul T.

AU - Iacob, Codrin

AU - McCormick, Steven A.

AU - Milman, Tatyana

N1 - Funding Information: The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this article. Publication of this article was supported (in part) by The Eye Cancer Foundation, Inc. ( http://eyecancerfoundation.net ) and the Ophthalmic Pathology Research Fund. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.

PY - 2013/1

Y1 - 2013/1

N2 - Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a " pseudomelanoma" , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

AB - Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a " pseudomelanoma" , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

KW - Benign nerve sheath tumor

KW - Choroidal neurilemmoma

KW - Choroidal schwannoma

KW - Intraocular neurilemmoma

KW - Intraocular schwannoma

KW - Pseudomelanoma

KW - Uveal neurilemmoma

KW - Uveal schwannoma

UR - http://www.scopus.com/inward/record.url?scp=84870838167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870838167&partnerID=8YFLogxK

U2 - 10.1016/j.survophthal.2012.04.003

DO - 10.1016/j.survophthal.2012.04.003

M3 - Review article

C2 - 22981398

AN - SCOPUS:84870838167

SN - 0039-6257

VL - 58

SP - 77

EP - 85

JO - Survey of ophthalmology

JF - Survey of ophthalmology

IS - 1

ER -

Intraocular Schwannoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this