Intraocular Schwannoma

Jae Young You; Paul T. Finger; Codrin Iacob; Steven A. McCormick; Tatyana Milman

doi:10.1016/j.survophthal.2012.04.003

Intraocular Schwannoma

Jae Young You, Paul T. Finger, Codrin Iacob, Steven A. McCormick, Tatyana Milman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a " pseudomelanoma" , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

Original language	English (US)
Pages (from-to)	77-85
Number of pages	9
Journal	Survey of ophthalmology
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/j.survophthal.2012.04.003
State	Published - Jan 1 2013

Keywords

Benign nerve sheath tumor
Choroidal neurilemmoma
Choroidal schwannoma
Intraocular neurilemmoma
Intraocular schwannoma
Pseudomelanoma
Uveal neurilemmoma
Uveal schwannoma

ASJC Scopus subject areas

Ophthalmology

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@article{717d2738e0354ea186448332dc3cc783,

title = "Intraocular Schwannoma",

abstract = "Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a {"} pseudomelanoma{"} , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.",

keywords = "Benign nerve sheath tumor, Choroidal neurilemmoma, Choroidal schwannoma, Intraocular neurilemmoma, Intraocular schwannoma, Pseudomelanoma, Uveal neurilemmoma, Uveal schwannoma",

author = "You, {Jae Young} and Finger, {Paul T.} and Codrin Iacob and McCormick, {Steven A.} and Tatyana Milman",

year = "2013",

month = jan,

day = "1",

doi = "10.1016/j.survophthal.2012.04.003",

language = "English (US)",

volume = "58",

pages = "77--85",

journal = "Survey of Ophthalmology",

issn = "0039-6257",

publisher = "Elsevier USA",

number = "1",

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TY - JOUR

T1 - Intraocular Schwannoma

AU - You, Jae Young

AU - Finger, Paul T.

AU - Iacob, Codrin

AU - McCormick, Steven A.

AU - Milman, Tatyana

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a " pseudomelanoma" , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

AB - Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a " pseudomelanoma" , reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

KW - Benign nerve sheath tumor

KW - Choroidal neurilemmoma

KW - Choroidal schwannoma

KW - Intraocular neurilemmoma

KW - Intraocular schwannoma

KW - Pseudomelanoma

KW - Uveal neurilemmoma

KW - Uveal schwannoma

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DO - 10.1016/j.survophthal.2012.04.003

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VL - 58

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JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

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