Intranasal steroids inhibit seasonal increases in ragweed-specific immunoglobulin IE antibodies

Robert M. Naclerio, N. Franklin Adkinson, Peter S. Creticos, Fuad M. Baroody, Robert G. Hamilton, Philip S. Norman

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


We performed two seasonal studies to evaluate the effect of continuous treatment with intranasal steroids, beginning approximately 1 week before the apperance of ragweed pollen, on the level of ragweed-specific IgE antibodies in serum. In both studies the control groups showed the anticipated rise in ragweed-specific IgE antibodies after the ragweed season. In the first study, employing aqueous beclomethasone dipropionate (168 μg twice daily), no rise occurred in serum ragweed IgE after seasonal exposure and the level actually decreased in eight of 12 treated subjects. In the second study, with triamcinolone acetonide (220 μg twice daily), the expected rise in ragweed IgE antibody was also reduced, although less dramatically, probably as a result of the lower potency of the dose delivered. Our studies not only support the benefits of intranasal steroids in the treatment of seasonal allergic rhinitis but also suggest that specific IgE production may be down-regulated by their continuous use, which may alter the subsequent clinical course of the disease.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalThe Journal of allergy and clinical immunology
Issue number5
StatePublished - Nov 1993
Externally publishedYes


  • Ragweed
  • allergic rhinitis
  • beclomethasone
  • intranasal steroids
  • serum ragweed IgE
  • triamcinolone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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