Crosslinks between the β82 lysines using 10, 12, and 14 carbon dicarboxylic acids is reported. It was found that the incubation mixture of human deoxyhemoglobin with bis- (3,5-dibromosalicyl)sebacate contains three main intramolecularly crosslinked molecular species. The major component is a hemoglobin crosslinked between the β82 lysines. These species have low oxygen affinity. Preliminary data suggest that the α subunits are crosslinked between the α99 residues.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1 1994|
|Event||Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA|
Duration: Jul 24 1994 → Jul 27 1994
ASJC Scopus subject areas
- Biomedical Engineering