Intramedullary Ewing sarcoma of the spinal cord: Consequences of molecular diagnostics

Robert J. Weil, Zhengping Zhuang, Svetlana Pack, Shimareet Kumar, Lee J. Helman, Brian G. Fuller, Crystall L. Mackall, Edward H. Oldfield

Research output: Contribution to journalArticle

Abstract

Molecular biological techniques have begun to transform modern medicine. These techniques have shown promise in the pathological diagnosis of difficult or uncommon tumors. Accurate molecular diagnosis of the small round-cell tumors, for example, is especially important because divergent therapies may be required to eradicate such disparate lesions as neuroblastoma, lymphoma, rhabdomyosarcoma, central primitive neuroectodermal tumors/medulloblastoma, or Ewing sarcoma (ES). The authors present an unusual case of a primary, extraosseous ES arising from the intramedullary spinal cord, in which molecular studies were required for specific diagnosis and therapeutic guidance.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalJournal of Neurosurgery
Volume95
Issue number2 SUPPL.
StatePublished - 2001
Externally publishedYes

Fingerprint

Ewing's Sarcoma
Molecular Pathology
Spinal Cord
Primitive Neuroectodermal Tumors
Modern 1601-history
Medulloblastoma
Rhabdomyosarcoma
Neuroblastoma
Lymphoma
Neoplasms
Therapeutics

Keywords

  • Chemotherapy
  • Chromosomal translocation
  • Ewing sarcoma
  • Radiation therapy
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Weil, R. J., Zhuang, Z., Pack, S., Kumar, S., Helman, L. J., Fuller, B. G., ... Oldfield, E. H. (2001). Intramedullary Ewing sarcoma of the spinal cord: Consequences of molecular diagnostics. Journal of Neurosurgery, 95(2 SUPPL.), 270-275.

Intramedullary Ewing sarcoma of the spinal cord : Consequences of molecular diagnostics. / Weil, Robert J.; Zhuang, Zhengping; Pack, Svetlana; Kumar, Shimareet; Helman, Lee J.; Fuller, Brian G.; Mackall, Crystall L.; Oldfield, Edward H.

In: Journal of Neurosurgery, Vol. 95, No. 2 SUPPL., 2001, p. 270-275.

Research output: Contribution to journalArticle

Weil, RJ, Zhuang, Z, Pack, S, Kumar, S, Helman, LJ, Fuller, BG, Mackall, CL & Oldfield, EH 2001, 'Intramedullary Ewing sarcoma of the spinal cord: Consequences of molecular diagnostics', Journal of Neurosurgery, vol. 95, no. 2 SUPPL., pp. 270-275.
Weil RJ, Zhuang Z, Pack S, Kumar S, Helman LJ, Fuller BG et al. Intramedullary Ewing sarcoma of the spinal cord: Consequences of molecular diagnostics. Journal of Neurosurgery. 2001;95(2 SUPPL.):270-275.
Weil, Robert J. ; Zhuang, Zhengping ; Pack, Svetlana ; Kumar, Shimareet ; Helman, Lee J. ; Fuller, Brian G. ; Mackall, Crystall L. ; Oldfield, Edward H. / Intramedullary Ewing sarcoma of the spinal cord : Consequences of molecular diagnostics. In: Journal of Neurosurgery. 2001 ; Vol. 95, No. 2 SUPPL. pp. 270-275.
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