Introduction: Laryngopharyngeal herpes simplex virus infection is rare and presents typically in the supraglottis. Findings on presentation can range from small mucosal lesions to fungating obstructive masses mimicking neoplasm. Laryngopharyngeal herpes is a medically treated disease. Objectives: Identify potential treatment in cases that are refractory to antiviral medications. Methods: Individual case with treatment adapted from other case report. Case Presentation: We report a case of bulky, obstructive supraglottic and glottic herpes virus laryngitis that presented with dysphonia, dysphagia, and airway complaints resistant to acyclovir analogues that was treated effectively with intralesional cidofovir injection. Conclusions: Our promising initial response suggests a potential novel treatment for this unusual condition.
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