Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses

Kathleen R. Stratton, Andrew J. Cole, John Pritchett, Christine U. Eccles, Paul F. Worley, Jay M. Baraban

Research output: Contribution to journalArticle

Abstract

Adenosine exerts prominent inhibitory effects on synaptic transmission via a presynaptic action. Using the hippocampal slice preparation, we have found in electrophysiological experiments that this action of adenosine is blocked by intrahippocampal injections of pertussis toxin. In biochemical studies, we have confirmed that this treatment affects the GTP-binding proteins, Gi and Go, in this preparation. These results indicate that both pre- and postsynaptic actions of adenosine involve pertussis toxin-sensitive GTP-binding proteins.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalBrain research
Volume494
Issue number2
DOIs
StatePublished - Aug 14 1989

Keywords

  • Adenosine
  • Caffeine
  • Guanosine triphosphate-binding protein
  • Hippocampus
  • Pertussis toxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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