Intraductal Therapy in Breast Cancer: Current Status and Future Prospective

Xin Wen Kuang, Jian Hua Liu, Zhi Hong Sun, Saraswati Sukumar, Sheng Rong Sun, Chuang Chen

Research output: Contribution to journalReview articlepeer-review


With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of entering the ducts may be used both to diagnose and treat lesions in the mammary duct system with less trauma and at the same time avoid systemic toxicity. Traditional agents such as those targeting pathways, endocrine therapy, immunotherapy, or gene therapy can be used alone or combined with other new technologies, such as nanomaterials, through the intraductal route. Additionally, relevant mammary tumor models in rodents which reflect changes in the tumor microenvironment will help deepen our understanding of their biological behavior and heterogeneity. This article reviews the current status and future prospects of intraductal therapy in breast cancer, with emphasis on ductal carcinoma in situ.

Original languageEnglish (US)
Pages (from-to)133-143
Number of pages11
JournalJournal of Mammary Gland Biology and Neoplasia
Issue number2
StatePublished - Jun 1 2020


  • Breast cancer
  • Ductal carcinoma in situ
  • Intraductal therapy
  • Minimally invasive
  • Nanomedicine
  • Personalized therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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