TY - JOUR
T1 - Intraductal Papillary Mucinous Neoplasm of the Pancreas in Young Patients
T2 - Tumor Biology, Clinical Features, and Survival Outcomes
AU - Morales-Oyarvide, Vicente
AU - Mino-Kenudson, Mari
AU - Ferrone, Cristina R.
AU - Warshaw, Andrew L.
AU - Lillemoe, Keith D.
AU - Sahani, Dushyant V.
AU - Pergolini, Ilaria
AU - Attiyeh, Marc A.
AU - Al Efishat, Mohammad
AU - Rezaee, Neda
AU - Hruban, Ralph H.
AU - He, Jin
AU - Weiss, Matthew J.
AU - Allen, Peter J.
AU - Wolfgang, Christopher L.
AU - Fernández-del Castillo, Carlos
N1 - Publisher Copyright:
© 2017, The Society for Surgery of the Alimentary Tract.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Aim: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. Methods: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features. Results: We identified 90 (5%) young patients. Age was not associated with differences in main pancreatic duct size (P = 0.323), presence of solid components (P = 0.805), or cyst size (P = 0.135). IPMNs from young patients were less likely to be of gastric type (37 vs. 57%, P = 0.005), and more likely to be of oncocytic (15 vs. 4%, P = 0.003) and intestinal types (44 vs. 26%, P = 0.004). Invasive carcinomas arising from IPMN were less common in young patients (17 vs. 27%, P = 0.044), and when present they were commonly of colloid type (47 vs. 31% in older patients, P = 0.261) and had better overall survival than older patients (5-year, 71 vs. 37%, log-rank P = 0.031). Conclusion: Resection for IPMN is infrequent in young patients, but when they are resected, IPMNs from young patients demonstrate different epithelial subtypes from those in older patients and more favorable prognosis.
AB - Aim: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. Methods: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features. Results: We identified 90 (5%) young patients. Age was not associated with differences in main pancreatic duct size (P = 0.323), presence of solid components (P = 0.805), or cyst size (P = 0.135). IPMNs from young patients were less likely to be of gastric type (37 vs. 57%, P = 0.005), and more likely to be of oncocytic (15 vs. 4%, P = 0.003) and intestinal types (44 vs. 26%, P = 0.004). Invasive carcinomas arising from IPMN were less common in young patients (17 vs. 27%, P = 0.044), and when present they were commonly of colloid type (47 vs. 31% in older patients, P = 0.261) and had better overall survival than older patients (5-year, 71 vs. 37%, log-rank P = 0.031). Conclusion: Resection for IPMN is infrequent in young patients, but when they are resected, IPMNs from young patients demonstrate different epithelial subtypes from those in older patients and more favorable prognosis.
KW - IPMN
KW - Pancreatic cystic neoplasms
KW - Young
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U2 - 10.1007/s11605-017-3602-z
DO - 10.1007/s11605-017-3602-z
M3 - Article
C2 - 29047068
AN - SCOPUS:85031754199
SN - 1091-255X
VL - 22
SP - 226
EP - 234
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 2
ER -