Intracytoplasmic sperm injection: Achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female and not male factors

S. Oehninger, L. Veeck, S. Lanzendorf, M. Maloney, J. Toner, S. Muasher

Research output: Contribution to journalArticle


Objective: To determine the efficacy and factors affecting outcome of intracytoplasmic sperm injection (ICSI) in patients with severe male factor infertility. Design: Prospectively designed clinical trial of patients selected to participate in the study based upon the following inclusion criteria: previous total failed fertilization or unsuitable sperm parameters for conventional IVF. Setting: Tertiary care academic center. Patients: Ninety-two consecutive couples undergoing IVF therapy augmented with ICSI during April through December 1994 were studied. Main Outcome Measures: Fertilization and ongoing implantation and pregnancy rates (PRs). Results: A total of 1,163 preovulatory oocytes were manipulated, yielding a diploid fertilization rate of 60.9%; the oocyte damage rate was 13.2%. The transfer rate was 95% with 43.1% of cycles having excess embryos that were cryopreserved. Overall, the clinical and ongoing PRs per transfer were 31.9% and 26.8%, respectively. None of the sperm parameters of the original semen analysis correlated with ICSI outcome. Female age did not affect fertilization results but had a significant impact on PR (<34 years: 48.9%; 35 to 39 years: 22.9%; ≥40 years: 5.9% clinical PR per transfer). Conclusions: Intracytoplasmic sperm injection offers a new and powerful therapeutic option to treat couples with severe male factor infertility associated with a variety of sperm abnormalities. An adequate female age is a pivotal factor determining a successful outcome.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalFertility and sterility
Issue number5
StatePublished - Jan 1 1995



  • ICSI
  • IVF
  • female age
  • male factor
  • sperm abnormalities

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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