Intractable postherpetic itch and cutaneous deafferentation after facial shingles

Anne Louise Oaklander, Steven P. Cohen, Shubha V.Y. Raju

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Some patients develop chronic itch from neurological injuries, and shingles may be a common cause. Neuropathic itch can lead to self-injury from scratching desensate skin. A 39-year-old woman experienced severe postherpetic itch, but no postherpetic neuralgia, after ophthalmic zoster. Within 1 year, she had painlessly scratched through her frontal skull into her brain. Sensory testing and skin biopsies were performed on itchy and normal scalp to generate preliminary hypotheses about mechanisms of neuropathic itch. Quantitation of epidermal neurites in PGP9.5-immunolabeled skin biopsies demonstrated loss of 96% of epidermal innervation in the itchy area. Quantitative sensory testing indicated severe damage to most sensory modalities except itch. These data indicate that in this patient, severe postherpetic itch was associated with loss of peripheral sensory neurons. Possible mechanisms include electrical hyperactivity of hypo-afferented central itch-specific neurons, selective preservation of peripheral itch-fibers from neighboring unaffected dermatomes, and/or imbalance between excitation and inhibition of second-order sensory neurons.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
Issue number1-2
StatePublished - 2002
Externally publishedYes


  • Herpes zoster
  • Human
  • Nervous system/physiopathology
  • Neuralgia
  • Postherpetic neuralgia
  • Pruritus/physiopathology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Intractable postherpetic itch and cutaneous deafferentation after facial shingles'. Together they form a unique fingerprint.

Cite this