Intracranial self-stimulation in 3-day-old rat pups

Timothy H. Moran, Mark F. Lew, Elliott M. Blass

Research output: Contribution to journalArticlepeer-review

Abstract

Three-day-old rat pups with electrodes directed at the medial forebrain bundle at the level of the lateral hypothalamic area were trained to push a paddle to receive electrical brain stimulation. Pups receiving stimulation that was contingent on lifting the paddle responded more frequently than did control pups and also learned a two-choice spatial discrimination task that was rewarded with brain stimulation. The experiments indicate that a neural substrate in the area of the medial forebrain bundle is involved in the central mediation of reinforcement in the rat pup.

Original languageEnglish (US)
Pages (from-to)1366-1368
Number of pages3
JournalScience
Volume214
Issue number4527
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • General

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