Intracranial pressure dose and outcome in traumatic brain injury

Kevin N. Sheth, Deborah M. Stein, Bizhan Aarabi, Peter Hu, Joseph A. Kufera, Thomas M. Scalea, Daniel F Hanley

Research output: Contribution to journalArticle

Abstract

Objective: Detecting and treating elevated intracranial pressure (ICP) is a cornerstone of management in patients with severe traumatic brain injury. The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome. Methods: Single center observational study using prospectively collected data at a University hospital, level one-trauma center. Sixty prospective patients with severe traumatic brain injury were prospectively enrolled over a 2-year period. Intracranial pressure measurements were captured using a real-time automated, high resolution vital signs data recording system. Mortality and functional outcome were assessed at 30 days, 3 and 6 months using Extended Glasgow Outcome Scale. Results: Increasing elevated intracranial pressure time dose was associated with mortality (OR 1.08; 95 % confidence interval [CI], 1.01-1.15, p = 0.03) and poor functional outcome at 3 (OR 1.04; CI 1.00-1.07, p = 0.03) and 6 months (1.04; CI 1.01-1.08, p = 0.02). However, there was no association between episodic ICP data and outcome. Conclusions: These results suggest that pressure time dose measurement of intracranial pressure may be used to predict outcome in severe traumatic brain injury and may be a candidate biomarker in this disease.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalNeurocritical Care
Volume18
Issue number1
DOIs
StatePublished - Feb 2013

Fingerprint

Intracranial Hypertension
Intracranial Pressure
Confidence Intervals
Glasgow Outcome Scale
Mortality
Vital Signs
Trauma Centers
Information Systems
Area Under Curve
Observational Studies
Biomarkers
Pressure
Traumatic Brain Injury

Keywords

  • Critical care
  • Head trauma
  • Intracranial pressure
  • Trauma
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Cite this

Sheth, K. N., Stein, D. M., Aarabi, B., Hu, P., Kufera, J. A., Scalea, T. M., & Hanley, D. F. (2013). Intracranial pressure dose and outcome in traumatic brain injury. Neurocritical Care, 18(1), 26-32. https://doi.org/10.1007/s12028-012-9780-3

Intracranial pressure dose and outcome in traumatic brain injury. / Sheth, Kevin N.; Stein, Deborah M.; Aarabi, Bizhan; Hu, Peter; Kufera, Joseph A.; Scalea, Thomas M.; Hanley, Daniel F.

In: Neurocritical Care, Vol. 18, No. 1, 02.2013, p. 26-32.

Research output: Contribution to journalArticle

Sheth, KN, Stein, DM, Aarabi, B, Hu, P, Kufera, JA, Scalea, TM & Hanley, DF 2013, 'Intracranial pressure dose and outcome in traumatic brain injury', Neurocritical Care, vol. 18, no. 1, pp. 26-32. https://doi.org/10.1007/s12028-012-9780-3
Sheth KN, Stein DM, Aarabi B, Hu P, Kufera JA, Scalea TM et al. Intracranial pressure dose and outcome in traumatic brain injury. Neurocritical Care. 2013 Feb;18(1):26-32. https://doi.org/10.1007/s12028-012-9780-3
Sheth, Kevin N. ; Stein, Deborah M. ; Aarabi, Bizhan ; Hu, Peter ; Kufera, Joseph A. ; Scalea, Thomas M. ; Hanley, Daniel F. / Intracranial pressure dose and outcome in traumatic brain injury. In: Neurocritical Care. 2013 ; Vol. 18, No. 1. pp. 26-32.
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