Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI

R. H. Swartz, S. S. Bhuta, R. I. Farb, R. Agid, R. A. Willinsky, K. G. Terbrugge, J. Butany, Bruce A Wasserman, D. M. Johnstone, F. L. Silver, D. J. Mikulis

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Conventional arterial imaging focuses on the vessel lumen but lacks specificity because different pathologies produce similar luminal defects. Wall imaging can characterize extracranial arterial pathology, but imaging intracranial walls has been limited by resolution and signal constraints. Higher-field scanners may improve visualization of these smaller vessels. METHODS: Three-tesla contrast-enhanced MRI was used to study the intracranial arteries from a consecutive series of patients at a tertiary stroke center. RESULTS: Multiplanar T2-weighted fast spin echo and multiplanar T1 fluid-attenuated inversion recovery precontrast and postcontrast images were acquired in 37 patients with focal neurologic deficits. Clinical diagnoses included atherosclerotic disease (13), CNS inflammatory disease (3), dissections (3), aneurysms (3), moyamoya syndrome (2), cavernous angioma (1), extracranial source of stroke (5), and no definitive clinical diagnosis (7). Twelve of 13 with atherosclerotic disease had focal, eccentric vessel wall enhancement, 10 of whom had enhancement only in the vessel supplying the area of ischemic injury. Two of 3 with inflammatory diseases had diffuse, concentric vessel wall enhancement. Three of 3 with dissection showed bright signal on T1, and 2 had irregular wall enhancement with a flap and dual lumen. CONCLUSIONS: Three-tesla contrast-enhanced MRI can be used to study the wall of intracranial blood vessels. T2 and precontrast and postcontrast T1 fluid-attenuated inversion recovery images at 3 tesla may be able to differentiate enhancement patterns of intracranial atherosclerotic plaques (eccentric), inflammation (concentric), and other wall pathologies. Prospective studies are required to determine the sensitivity and specificity of arterial wall imaging for distinguishing the range of pathologic conditions affecting cerebral vasculature.

Original languageEnglish (US)
Pages (from-to)627-634
Number of pages8
JournalNeurology
Volume72
Issue number7
DOIs
StatePublished - Feb 17 2009

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Pathology
Dissection
Stroke
Moyamoya Disease
Cavernous Hemangioma
Central Nervous System Diseases
Atherosclerotic Plaques
Neurologic Manifestations
Aneurysm
Blood Vessels
Arteries
Prospective Studies
Inflammation
Sensitivity and Specificity
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Swartz, R. H., Bhuta, S. S., Farb, R. I., Agid, R., Willinsky, R. A., Terbrugge, K. G., ... Mikulis, D. J. (2009). Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI. Neurology, 72(7), 627-634. https://doi.org/10.1212/01.wnl.0000342470.69739.b3

Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI. / Swartz, R. H.; Bhuta, S. S.; Farb, R. I.; Agid, R.; Willinsky, R. A.; Terbrugge, K. G.; Butany, J.; Wasserman, Bruce A; Johnstone, D. M.; Silver, F. L.; Mikulis, D. J.

In: Neurology, Vol. 72, No. 7, 17.02.2009, p. 627-634.

Research output: Contribution to journalArticle

Swartz, RH, Bhuta, SS, Farb, RI, Agid, R, Willinsky, RA, Terbrugge, KG, Butany, J, Wasserman, BA, Johnstone, DM, Silver, FL & Mikulis, DJ 2009, 'Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI', Neurology, vol. 72, no. 7, pp. 627-634. https://doi.org/10.1212/01.wnl.0000342470.69739.b3
Swartz RH, Bhuta SS, Farb RI, Agid R, Willinsky RA, Terbrugge KG et al. Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI. Neurology. 2009 Feb 17;72(7):627-634. https://doi.org/10.1212/01.wnl.0000342470.69739.b3
Swartz, R. H. ; Bhuta, S. S. ; Farb, R. I. ; Agid, R. ; Willinsky, R. A. ; Terbrugge, K. G. ; Butany, J. ; Wasserman, Bruce A ; Johnstone, D. M. ; Silver, F. L. ; Mikulis, D. J. / Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI. In: Neurology. 2009 ; Vol. 72, No. 7. pp. 627-634.
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abstract = "BACKGROUND: Conventional arterial imaging focuses on the vessel lumen but lacks specificity because different pathologies produce similar luminal defects. Wall imaging can characterize extracranial arterial pathology, but imaging intracranial walls has been limited by resolution and signal constraints. Higher-field scanners may improve visualization of these smaller vessels. METHODS: Three-tesla contrast-enhanced MRI was used to study the intracranial arteries from a consecutive series of patients at a tertiary stroke center. RESULTS: Multiplanar T2-weighted fast spin echo and multiplanar T1 fluid-attenuated inversion recovery precontrast and postcontrast images were acquired in 37 patients with focal neurologic deficits. Clinical diagnoses included atherosclerotic disease (13), CNS inflammatory disease (3), dissections (3), aneurysms (3), moyamoya syndrome (2), cavernous angioma (1), extracranial source of stroke (5), and no definitive clinical diagnosis (7). Twelve of 13 with atherosclerotic disease had focal, eccentric vessel wall enhancement, 10 of whom had enhancement only in the vessel supplying the area of ischemic injury. Two of 3 with inflammatory diseases had diffuse, concentric vessel wall enhancement. Three of 3 with dissection showed bright signal on T1, and 2 had irregular wall enhancement with a flap and dual lumen. CONCLUSIONS: Three-tesla contrast-enhanced MRI can be used to study the wall of intracranial blood vessels. T2 and precontrast and postcontrast T1 fluid-attenuated inversion recovery images at 3 tesla may be able to differentiate enhancement patterns of intracranial atherosclerotic plaques (eccentric), inflammation (concentric), and other wall pathologies. Prospective studies are required to determine the sensitivity and specificity of arterial wall imaging for distinguishing the range of pathologic conditions affecting cerebral vasculature.",
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AU - Willinsky, R. A.

AU - Terbrugge, K. G.

AU - Butany, J.

AU - Wasserman, Bruce A

AU - Johnstone, D. M.

AU - Silver, F. L.

AU - Mikulis, D. J.

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N2 - BACKGROUND: Conventional arterial imaging focuses on the vessel lumen but lacks specificity because different pathologies produce similar luminal defects. Wall imaging can characterize extracranial arterial pathology, but imaging intracranial walls has been limited by resolution and signal constraints. Higher-field scanners may improve visualization of these smaller vessels. METHODS: Three-tesla contrast-enhanced MRI was used to study the intracranial arteries from a consecutive series of patients at a tertiary stroke center. RESULTS: Multiplanar T2-weighted fast spin echo and multiplanar T1 fluid-attenuated inversion recovery precontrast and postcontrast images were acquired in 37 patients with focal neurologic deficits. Clinical diagnoses included atherosclerotic disease (13), CNS inflammatory disease (3), dissections (3), aneurysms (3), moyamoya syndrome (2), cavernous angioma (1), extracranial source of stroke (5), and no definitive clinical diagnosis (7). Twelve of 13 with atherosclerotic disease had focal, eccentric vessel wall enhancement, 10 of whom had enhancement only in the vessel supplying the area of ischemic injury. Two of 3 with inflammatory diseases had diffuse, concentric vessel wall enhancement. Three of 3 with dissection showed bright signal on T1, and 2 had irregular wall enhancement with a flap and dual lumen. CONCLUSIONS: Three-tesla contrast-enhanced MRI can be used to study the wall of intracranial blood vessels. T2 and precontrast and postcontrast T1 fluid-attenuated inversion recovery images at 3 tesla may be able to differentiate enhancement patterns of intracranial atherosclerotic plaques (eccentric), inflammation (concentric), and other wall pathologies. Prospective studies are required to determine the sensitivity and specificity of arterial wall imaging for distinguishing the range of pathologic conditions affecting cerebral vasculature.

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