Intracortical kainic acid induces an assymmetrical behavioral response in the rat

Kenneth L. Kubos; Godfrey D. Pearlson; Robert G. Robinson

doi:10.1016/0006-8993(82)90857-5

Intracortical kainic acid induces an assymmetrical behavioral response in the rat

Kenneth L. Kubos, Godfrey D. Pearlson, Robert G. Robinson

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Five nanomolar doses of kainic acid injected into the right frontal cortex of rats produced a significantly greater spontaneous hyperactivity than identical injections into the left hemisphere. Hyperactivity began one week after injection and slowly continued to increase throughout the 30 day postoperative period. These results taken with our previous studies suggest that the neural asymmetry which leads to hyperactivity following right hemisphere lesions may be postsynaptic to cortical noradrenergic terminals.

Original language	English (US)
Pages (from-to)	303-309
Number of pages	7
Journal	Brain research
Volume	239
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)90857-5
State	Published - May 6 1982
Externally published	Yes

Keywords

asymmetry
cerebral cortex
kainic acid
spontaneous activity

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(82)90857-5

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AB - Five nanomolar doses of kainic acid injected into the right frontal cortex of rats produced a significantly greater spontaneous hyperactivity than identical injections into the left hemisphere. Hyperactivity began one week after injection and slowly continued to increase throughout the 30 day postoperative period. These results taken with our previous studies suggest that the neural asymmetry which leads to hyperactivity following right hemisphere lesions may be postsynaptic to cortical noradrenergic terminals.

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Intracortical kainic acid induces an assymmetrical behavioral response in the rat

Abstract

Keywords

ASJC Scopus subject areas

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