Intracortical kainic acid induces an assymmetrical behavioral response in the rat

Kenneth L. Kubos, Godfrey D. Pearlson, Robert G. Robinson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Five nanomolar doses of kainic acid injected into the right frontal cortex of rats produced a significantly greater spontaneous hyperactivity than identical injections into the left hemisphere. Hyperactivity began one week after injection and slowly continued to increase throughout the 30 day postoperative period. These results taken with our previous studies suggest that the neural asymmetry which leads to hyperactivity following right hemisphere lesions may be postsynaptic to cortical noradrenergic terminals.

    Original languageEnglish (US)
    Pages (from-to)303-309
    Number of pages7
    JournalBrain research
    Volume239
    Issue number1
    DOIs
    StatePublished - May 6 1982

    Keywords

    • asymmetry
    • cerebral cortex
    • kainic acid
    • spontaneous activity

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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