Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine

Victor L. Serebruany, Matthew L. Schlossberg, Lisa R. Edenbau, William R. Herzog, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

The use of calcium antagonists and magnesium (Mg) in the treatment of acute myocardial infarction is controversial. We compared changes in hemostasis during acute myocardial infarction after either low-dose intracoronary Mg or diltiazem infusion in 20 Yorkshire swine undergoing thoracotomy and coronary artery occlusion for 50 min, followed by 3 h of reperfusion. The first group received MgSO4 (250 mg), delivered at the onset of reperfusion, the second group received diltiazem (2.5 mg) at the beginning of reperfusion. Six controls received saline. Plasma antithrombin III, protein C, total protein S, fibronectin, endothelin 1, and metabolites of thromboxane and prostacyclin were measured at baseline, twice during occlusion, and three times during reperfusion. Compared to controls, Mg and diltiazem infusion diminished endothelin 1 (32.9 vs. 34.5%) and fibronectin (21.7 vs. 23.2%), but increased protein C (31.9 vs. 29.3%). Intracoronary Mg, like diltiazem, improved hemostasis in swine.

Original languageEnglish (US)
Pages (from-to)224-233
Number of pages10
JournalPharmacology
Volume53
Issue number4
DOIs
StatePublished - Jan 1 1996

Keywords

  • Animal model
  • Diltiazem
  • Hemostasis
  • Magnesium
  • Myocardial infarction

ASJC Scopus subject areas

  • Pharmacology

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