Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy

Roberto Bolli, Xian Liang Tang, Santosh K. Sanganalmath, Ornella Rimoldi, Federico Mosna, Ahmed Abdel-Latif, Hani Jneid, Marcello Rota, Annarosa Leri, Jan Kajstura

Research output: Contribution to journalArticle

Abstract

Background- Relevant preclinical models are necessary for further mechanistic and translational studies of c-kit+ cardiac stem cells (CSCs). The present study was undertaken to determine whether intracoronary CSCs are beneficial in a porcine model of chronic ischemic cardiomyopathy. Methods and Results-Pigs underwent a 90-minute coronary occlusion followed by reperfusion. Three months later, autologous CSCs (n=11) or vehicle (n=10) were infused into the infarct-related artery. At this time, all indices of left ventricular (LV) function were similar in control and CSC-treated pigs, indicating that the damage inflicted by the infarct in the 2 groups was similar; 1 month later, however, CSC-treated pigs exhibited significantly greater LV ejection fraction (echocardiography) (51.7±2.0% versus 42.9±2.3%, P

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalCirculation
Volume128
Issue number2
DOIs
StatePublished - Jul 9 2013
Externally publishedYes

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Cardiomyopathies
Swine
Stem Cells
Coronary Occlusion
Left Ventricular Function
Stroke Volume
Reperfusion
Echocardiography
Arteries

Keywords

  • angiogenesis inducers
  • heart failure
  • muscle development
  • myocardial infarction
  • stem cells

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Bolli, R., Tang, X. L., Sanganalmath, S. K., Rimoldi, O., Mosna, F., Abdel-Latif, A., ... Kajstura, J. (2013). Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy. Circulation, 128(2), 122-131. https://doi.org/10.1161/CIRCULATIONAHA.112.001075

Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy. / Bolli, Roberto; Tang, Xian Liang; Sanganalmath, Santosh K.; Rimoldi, Ornella; Mosna, Federico; Abdel-Latif, Ahmed; Jneid, Hani; Rota, Marcello; Leri, Annarosa; Kajstura, Jan.

In: Circulation, Vol. 128, No. 2, 09.07.2013, p. 122-131.

Research output: Contribution to journalArticle

Bolli, R, Tang, XL, Sanganalmath, SK, Rimoldi, O, Mosna, F, Abdel-Latif, A, Jneid, H, Rota, M, Leri, A & Kajstura, J 2013, 'Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy', Circulation, vol. 128, no. 2, pp. 122-131. https://doi.org/10.1161/CIRCULATIONAHA.112.001075
Bolli, Roberto ; Tang, Xian Liang ; Sanganalmath, Santosh K. ; Rimoldi, Ornella ; Mosna, Federico ; Abdel-Latif, Ahmed ; Jneid, Hani ; Rota, Marcello ; Leri, Annarosa ; Kajstura, Jan. / Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy. In: Circulation. 2013 ; Vol. 128, No. 2. pp. 122-131.
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