Intracerebral Inoculation of Experimental Animals With Brain Tissue From Patients With Schizophrenia: Failure to Observe Consistent or Specific Behavioral and Neuropathological Effects

Charles A. Kaufmann, Daniel R. Weinberger, Janice R. Stevens, David M. Asher, Joel E. Kleinman, Michael P. Sulima, Clarence J. Gibbs, D. Carleton Gajdusek

Research output: Contribution to journalArticlepeer-review

Abstract

To test the possibility that some cases of schizophrenia result from infection with a transmissible slow viral agent, 57 experimental animals (six chimpanzees, 12 Old World monkeys, 17 New World monkeys, and 22 guinea pigs) were inoculated intracerebrally with brain tissue from ten patients and followed up for six years. Behavioral comparisons with control animals revealed no consistent behavioral differences. Histological, immunohistochemical, and morphometric examination of brains of animals that died revealed no specific neuropathological abnormalities. These findings do not support a role for a virus-induced slow infection in the pathogenesis of schizophrenia but must be weighed against methodological limitations in animal susceptibility, disease communicability, and assay sensitivity.

Original languageEnglish (US)
Pages (from-to)648-652
Number of pages5
JournalArchives of general psychiatry
Volume45
Issue number7
DOIs
StatePublished - Jul 1988
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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