Intracerebral hemorrhages associated with neurointerventional procedures using a combination of antithrombotic agents including abciximab

Adnan I. Qureshi, Mustafa Saad, Osama O. Zaidat, Jose I. Suarez, Michael J. Alexander, M. Fareed, K. Suri, Zulfiqar Ali, L. Nelson Hopkins

Research output: Contribution to journalArticle

Abstract

Background - We report the occurrence of fatal intracerebral hemorrhage associated with using a combination of antithrombotic agents, including abciximab, in patients undergoing neurointerventional procedures. Summary of Report - Seven patients (average age 60, range 46 to 73 years) developed fatal intracerebral hemorrhages associated with neurointerventional procedures and the use of intravenous abciximab. The procedures included angioplasty and stent placement in the cervical internal carotid artery (n=4), angioplasty of the intracranial internal carotid artery (n=1), and angioplasty of the middle cerebral artery (n=2). Clinical deterioration was observed within 1 hour of the procedure in 5 patients and 7 and 8 hours after the procedure, respectively, in the remaining 2 patients. All patients had received heparin and clopidogrel; 6 had also received aspirin. Conclusions - Intracerebral hemorrhages can occur after neurointerventional procedures in patients with recent cerebral ischemic events, particularly when aggressive antithrombotic treatment is used.

Original languageEnglish (US)
Pages (from-to)1916-1919
Number of pages4
JournalStroke
Volume33
Issue number7
DOIs
StatePublished - Jul 23 2002
Externally publishedYes

Keywords

  • Abciximab
  • Angioplasty
  • Carotid stenosis
  • Intracerebral hemorrhage
  • Stents

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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