Intracerebral Hemorrhages and Infarction Induced by a Murine Leukemia Virus Is Influenced by Host Determinants within Endothelial Cells

Ben Ho Park, Ehud Lavi, Glen N. Gaulton

Research output: Contribution to journalArticle

Abstract

The strain and developmental parameters that control susceptibility to murine leukemia virus (MuLV)-induced intracerebral hemorrhages and infarction were studied using the endothelial cell tropic MuLV TR1.3. Inoculated animals displayed an absolute age dependence on the development of intracerebral vascular disease; however, other genetic determinants affected the timing and magnitude of susceptibility to neurologic disease. BALB/c mice were susceptible to neurologic disease only when inoculated prior to Day 4 postpartum. In contrast, Swiss/NIH and C3H/HeN mice consistently showed a less virulent phenotype and were only susceptible when infected prior to Day 3 postpartum. These studies demonstrate that susceptibility to TR1.3 murine leukemia virus-induced neurologic disease is regulated by age- and strain-dependent factors encoded within cerebral endothelial cells.

Original languageEnglish (US)
Pages (from-to)393-396
Number of pages4
JournalVirology
Volume203
Issue number2
DOIs
StatePublished - Sep 1994
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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