Intracerebral hemorrhage: Perihemorrhagic edema and secondary hematoma expansion: From bench work to ongoing controversies

Manoj K. Mittal, Aaron LacKamp

Research output: Contribution to journalReview articlepeer-review

Abstract

Intracerebral hemorrhage (ICH) is a medical emergency, which often leads to severe disability and death. ICH-related poor outcomes are due to primary injury causing structural damage and mass effect and secondary injury in the perihemorrhagic region over several days to weeks. Secondary injury after ICH can be due to hematoma expansion (HE) or a consequence of repair pathway along the continuum of neuroinflammation, neuronal death, and perihemorrhagic edema (PHE). This review article is focused on PHE and HE and will cover the animal studies, related human studies, and clinical trials relating to these mechanisms of secondary brain injury in ICH patients.

Original languageEnglish (US)
Article number210
JournalFrontiers in Neurology
Volume7
Issue numberNOV
DOIs
StatePublished - Nov 21 2016

Keywords

  • Hematoma expansion
  • Intracerebral hemorrhage
  • Perihemorrhagic edema
  • Secondary brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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