TY - JOUR
T1 - Intracerebral hemorrhage
T2 - Perihemorrhagic edema and secondary hematoma expansion: From bench work to ongoing controversies
AU - Mittal, Manoj K.
AU - LacKamp, Aaron
N1 - Publisher Copyright:
© 2016 Mittal and LacKamp.
PY - 2016/11/21
Y1 - 2016/11/21
N2 - Intracerebral hemorrhage (ICH) is a medical emergency, which often leads to severe disability and death. ICH-related poor outcomes are due to primary injury causing structural damage and mass effect and secondary injury in the perihemorrhagic region over several days to weeks. Secondary injury after ICH can be due to hematoma expansion (HE) or a consequence of repair pathway along the continuum of neuroinflammation, neuronal death, and perihemorrhagic edema (PHE). This review article is focused on PHE and HE and will cover the animal studies, related human studies, and clinical trials relating to these mechanisms of secondary brain injury in ICH patients.
AB - Intracerebral hemorrhage (ICH) is a medical emergency, which often leads to severe disability and death. ICH-related poor outcomes are due to primary injury causing structural damage and mass effect and secondary injury in the perihemorrhagic region over several days to weeks. Secondary injury after ICH can be due to hematoma expansion (HE) or a consequence of repair pathway along the continuum of neuroinflammation, neuronal death, and perihemorrhagic edema (PHE). This review article is focused on PHE and HE and will cover the animal studies, related human studies, and clinical trials relating to these mechanisms of secondary brain injury in ICH patients.
KW - Hematoma expansion
KW - Intracerebral hemorrhage
KW - Perihemorrhagic edema
KW - Secondary brain injury
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U2 - 10.3389/fneur.2016.00210
DO - 10.3389/fneur.2016.00210
M3 - Review article
C2 - 27917153
AN - SCOPUS:85006483299
SN - 1664-2295
VL - 7
JO - Frontiers in Neurology
JF - Frontiers in Neurology
IS - NOV
M1 - 210
ER -