Intracerebral haemorrhage

current approaches to acute management

Charlotte Cordonnier, Andrew Demchuk, Wendy C Ziai, Craig S. Anderson

Research output: Contribution to journalReview article

Abstract

Acute spontaneous intracerebral haemorrhage is a life-threatening illness of global importance, with a poor prognosis and few proven treatments. As a heterogeneous disease, certain clinical and imaging features help identify the cause, prognosis, and how to manage the disease. Survival and recovery from intracerebral haemorrhage are related to the site, mass effect, and intracranial pressure from the underlying haematoma, and by subsequent cerebral oedema from perihaematomal neurotoxicity or inflammation and complications from prolonged neurological dysfunction. A moderate level of evidence supports there being beneficial effects of active management goals with avoidance of early palliative care orders, well-coordinated specialist stroke unit care, targeted neurointensive and surgical interventions, early control of elevated blood pressure, and rapid reversal of abnormal coagulation.

Original languageEnglish (US)
Pages (from-to)1257-1268
Number of pages12
JournalThe Lancet
Volume392
Issue number10154
DOIs
StatePublished - Oct 1 2018

Fingerprint

Cerebral Hemorrhage
Brain Edema
Intracranial Pressure
Palliative Care
Hematoma
Stroke
Blood Pressure
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Intracerebral haemorrhage : current approaches to acute management. / Cordonnier, Charlotte; Demchuk, Andrew; Ziai, Wendy C; Anderson, Craig S.

In: The Lancet, Vol. 392, No. 10154, 01.10.2018, p. 1257-1268.

Research output: Contribution to journalReview article

Cordonnier, C, Demchuk, A, Ziai, WC & Anderson, CS 2018, 'Intracerebral haemorrhage: current approaches to acute management', The Lancet, vol. 392, no. 10154, pp. 1257-1268. https://doi.org/10.1016/S0140-6736(18)31878-6
Cordonnier, Charlotte ; Demchuk, Andrew ; Ziai, Wendy C ; Anderson, Craig S. / Intracerebral haemorrhage : current approaches to acute management. In: The Lancet. 2018 ; Vol. 392, No. 10154. pp. 1257-1268.
@article{edab1e6aad054522838c851ebf62944c,
title = "Intracerebral haemorrhage: current approaches to acute management",
abstract = "Acute spontaneous intracerebral haemorrhage is a life-threatening illness of global importance, with a poor prognosis and few proven treatments. As a heterogeneous disease, certain clinical and imaging features help identify the cause, prognosis, and how to manage the disease. Survival and recovery from intracerebral haemorrhage are related to the site, mass effect, and intracranial pressure from the underlying haematoma, and by subsequent cerebral oedema from perihaematomal neurotoxicity or inflammation and complications from prolonged neurological dysfunction. A moderate level of evidence supports there being beneficial effects of active management goals with avoidance of early palliative care orders, well-coordinated specialist stroke unit care, targeted neurointensive and surgical interventions, early control of elevated blood pressure, and rapid reversal of abnormal coagulation.",
author = "Charlotte Cordonnier and Andrew Demchuk and Ziai, {Wendy C} and Anderson, {Craig S.}",
year = "2018",
month = "10",
day = "1",
doi = "10.1016/S0140-6736(18)31878-6",
language = "English (US)",
volume = "392",
pages = "1257--1268",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "10154",

}

TY - JOUR

T1 - Intracerebral haemorrhage

T2 - current approaches to acute management

AU - Cordonnier, Charlotte

AU - Demchuk, Andrew

AU - Ziai, Wendy C

AU - Anderson, Craig S.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Acute spontaneous intracerebral haemorrhage is a life-threatening illness of global importance, with a poor prognosis and few proven treatments. As a heterogeneous disease, certain clinical and imaging features help identify the cause, prognosis, and how to manage the disease. Survival and recovery from intracerebral haemorrhage are related to the site, mass effect, and intracranial pressure from the underlying haematoma, and by subsequent cerebral oedema from perihaematomal neurotoxicity or inflammation and complications from prolonged neurological dysfunction. A moderate level of evidence supports there being beneficial effects of active management goals with avoidance of early palliative care orders, well-coordinated specialist stroke unit care, targeted neurointensive and surgical interventions, early control of elevated blood pressure, and rapid reversal of abnormal coagulation.

AB - Acute spontaneous intracerebral haemorrhage is a life-threatening illness of global importance, with a poor prognosis and few proven treatments. As a heterogeneous disease, certain clinical and imaging features help identify the cause, prognosis, and how to manage the disease. Survival and recovery from intracerebral haemorrhage are related to the site, mass effect, and intracranial pressure from the underlying haematoma, and by subsequent cerebral oedema from perihaematomal neurotoxicity or inflammation and complications from prolonged neurological dysfunction. A moderate level of evidence supports there being beneficial effects of active management goals with avoidance of early palliative care orders, well-coordinated specialist stroke unit care, targeted neurointensive and surgical interventions, early control of elevated blood pressure, and rapid reversal of abnormal coagulation.

UR - http://www.scopus.com/inward/record.url?scp=85054286778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054286778&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(18)31878-6

DO - 10.1016/S0140-6736(18)31878-6

M3 - Review article

VL - 392

SP - 1257

EP - 1268

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 10154

ER -