Intracellular redox regulation by the family of small GTPases

Toren Finkel

Research output: Contribution to journalArticlepeer-review


There is growing experimental evidence that the production of intracellular reactive oxygen species (ROS) represents a tightly regulated process. In particular, numerous observations have suggested a role for the Ras superfamily of small GTPases in redox regulation. This article reviews the evidence that ROS can serve as important downstream effectors for both Ras and Rac proteins. Given the prominent role these proteins play in regulating growth, senescence, and transformation, understanding the role of the small GTPase family in redox regulation may significantly alter our current concepts as to how free radicals contribute to diverse processes from aging to cancer.

Original languageEnglish (US)
Pages (from-to)1857-1863
Number of pages7
JournalAntioxidants and Redox Signaling
Issue number9-10
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry


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