Intracellular metallothionein concentration and the rate of zinc or cadmium influx and MT mRNA accumulation in a CHO Cdr variant

Sheldon Morris, P. C. Huang

Research output: Contribution to journalArticle

Abstract

The regulation of metallothionein (MT) gene expression in a cadmium resistant CHO cell line which overproduces MT was examined in this study. Our results show that MT mRNA levels reach a maximum 24-30 h after a primary zinc exposure and, subsequently, MT mRNA concentrations decline. This decrease in MT mRNA levels can be correlated with the accumulation of metallothionein and decreased rates of zinc and cadmium uptake.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalExperimental cell research
Volume185
Issue number1
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Cell Biology

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