Intracellular Calcium and Neuronal Death

M. Gleichmann, M. P. Mattson

Research output: Chapter in Book/Report/Conference proceedingChapter


The connection between calcium and neuronal death is twofold. On the one hand, neuronal survival and functioning are sustained by synaptic activity and thus glutamate-mediated excitatory neurotransmission and depolarization, which is associated with calcium influx and its functions as a second messenger. On the other hand, calcium is a key contributor to excitotoxic neuronal death, which is supposed to be involved in stroke and a number of chronic neurodegenerative diseases. In this article, we take a closer look at the molecular events in neurons taking place in these scenarios and evaluate the evidence supporting either concept as relevant in the regulation of CNS function in later stages of life.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages6
ISBN (Print)9780080450469
StatePublished - 2010
Externally publishedYes


  • BDNF
  • Calmodulin kinase
  • Calpain
  • CREB
  • Excitotoxicity
  • Glutamate
  • Mitochondria
  • NCX
  • Stroke
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)


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