Intracellular calcium and myocardial function during ischemia

D. G. Allen, S. P. Cairns, S. E. Turvey, J. A. Lee, Y. Rudy, E. Marban, G. Hasenfuss, J. De Mey, W. M. Chilian

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac ischemia causes a rapid decline in mechanical performance and, if prolonged, myocardial cell death occurs on reperfusion. The early decline in mechanical performance could, in principle, be caused either by reduced intracellular calcium release or by reduced responsiveness of the myofibrillar proteins to calcium. It is now known that intracellular calcium rises during ischemia and that the early decline in mechanical performance is caused largely by the inhibitory effects of phosphate and protons on the myofibrillar proteins. The rise of intracellular calcium during ischemia is related to the acidosis and is probably caused by calcium influx on the Na/Ca exchanger. This is triggered by a rise in intracellular sodium which enter the cell in exchange for protons on the Na/H exchanger. Intracellular calcium rises still further on reperfusion and the elevation of calcium and the degree of muscle damage are closely correlated.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalAdvances in Experimental Medicine and Biology
Volume346
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Intracellular calcium and myocardial function during ischemia'. Together they form a unique fingerprint.

Cite this