Intracellular and nuclear localization of cyclosporine in peripheral blood mononuclear cells

A. D. Hess; T. Tuszynski; P. Engel; P. M. Colombani; J. Farrington; R. Wenger; B. Ryffel

Intracellular and nuclear localization of cyclosporine in peripheral blood mononuclear cells

A. D. Hess, T. Tuszynski, P. Engel, P. M. Colombani, J. Farrington, R. Wenger, B. Ryffel

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The present studies utilizing a photoactive radiolabelled derivative of cyclosporine demonstrate that, within one hour, CsA is internalized within the cytoplasm and nucleus of the cell and binds to several small molecular weight proteins including calmodulin. Taken together, it appears that the action of cyclosporine is not a membrane event but, rather, mediates its action intracellularly.

Original language	English (US)
Pages (from-to)	861-865
Number of pages	5
Journal	Transplantation proceedings
Volume	18
Issue number	4
State	Published - Jan 1 1986

ASJC Scopus subject areas

Surgery
Transplantation

Cite this

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title = "Intracellular and nuclear localization of cyclosporine in peripheral blood mononuclear cells",

abstract = "The present studies utilizing a photoactive radiolabelled derivative of cyclosporine demonstrate that, within one hour, CsA is internalized within the cytoplasm and nucleus of the cell and binds to several small molecular weight proteins including calmodulin. Taken together, it appears that the action of cyclosporine is not a membrane event but, rather, mediates its action intracellularly.",

author = "Hess, {A. D.} and T. Tuszynski and P. Engel and Colombani, {P. M.} and J. Farrington and R. Wenger and B. Ryffel",

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T1 - Intracellular and nuclear localization of cyclosporine in peripheral blood mononuclear cells

AU - Hess, A. D.

AU - Tuszynski, T.

AU - Engel, P.

AU - Colombani, P. M.

AU - Farrington, J.

AU - Wenger, R.

AU - Ryffel, B.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The present studies utilizing a photoactive radiolabelled derivative of cyclosporine demonstrate that, within one hour, CsA is internalized within the cytoplasm and nucleus of the cell and binds to several small molecular weight proteins including calmodulin. Taken together, it appears that the action of cyclosporine is not a membrane event but, rather, mediates its action intracellularly.

AB - The present studies utilizing a photoactive radiolabelled derivative of cyclosporine demonstrate that, within one hour, CsA is internalized within the cytoplasm and nucleus of the cell and binds to several small molecular weight proteins including calmodulin. Taken together, it appears that the action of cyclosporine is not a membrane event but, rather, mediates its action intracellularly.

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M3 - Article

AN - SCOPUS:0022893576

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ER -

Intracellular and nuclear localization of cyclosporine in peripheral blood mononuclear cells

Abstract

ASJC Scopus subject areas

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