Intracellular and nuclear localization of cyclosporine in peripheral blood mononuclear cells

A. D. Hess, T. Tuszynski, P. Engel, P. M. Colombani, J. Farrington, R. Wenger, B. Ryffel

Research output: Contribution to journalArticlepeer-review

Abstract

The present studies utilizing a photoactive radiolabelled derivative of cyclosporine demonstrate that, within one hour, CsA is internalized within the cytoplasm and nucleus of the cell and binds to several small molecular weight proteins including calmodulin. Taken together, it appears that the action of cyclosporine is not a membrane event but, rather, mediates its action intracellularly.

Original languageEnglish (US)
Pages (from-to)861-865
Number of pages5
JournalTransplantation proceedings
Volume18
Issue number4
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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