The present studies utilizing a photoactive radiolabelled derivative of cyclosporine demonstrate that, within one hour, CsA is internalized within the cytoplasm and nucleus of the cell and binds to several small molecular weight proteins including calmodulin. Taken together, it appears that the action of cyclosporine is not a membrane event but, rather, mediates its action intracellularly.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Jan 1 1986|
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