Intracellular α2C-Adrenoceptors: Storage depot, stunted development or signaling domain?

Maqsood A. Chotani, Nicholas A. Flavahan

Research output: Contribution to journalReview article

Abstract

G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α2C-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.

Original languageEnglish (US)
Pages (from-to)1495-1503
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1813
Issue number8
DOIs
StatePublished - Aug 1 2011

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Keywords

  • Cold
  • Endoplasmic Reticulum
  • Golgi
  • Signal transduction

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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