Intracellular α2C-Adrenoceptors

Storage depot, stunted development or signaling domain?

Maqsood A. Chotani, Nicholas Flavahan

Research output: Contribution to journalArticle

Abstract

G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α2C-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.

Original languageEnglish (US)
Pages (from-to)1495-1503
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1813
Issue number8
DOIs
StatePublished - Aug 2011

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G-Protein-Coupled Receptors
Adrenergic Receptors
Organelles
Cell Membrane

Keywords

  • Cold
  • Endoplasmic Reticulum
  • Golgi
  • Signal transduction

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Intracellular α2C-Adrenoceptors : Storage depot, stunted development or signaling domain? / Chotani, Maqsood A.; Flavahan, Nicholas.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1813, No. 8, 08.2011, p. 1495-1503.

Research output: Contribution to journalArticle

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