Intra-operative prostate brachytherapy dosimetry based on partial seed localization in ultrasound and registration to C-arm fluoroscopy.

Mehdi Moradi, Sara S. Mahdavi, Sanchit Deshmukh, Julio Lobo, Ehsan Dehghan, Gabor Fichtinger, William J. Morris, Septimiu E. Salcudean

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Intraoperative dosimetry during prostate brachytherapy is a long standing clinical problem. We propose a novel framework to address this problem by reliable detection of a subset of seeds from 3D transrectal ultrasound and registration to fluoroscopy. Seed detection in ultrasound is achieved through template matching in the RF ultrasound domain followed by thresholding and spatial filtering based on the fixed distance between stranded seeds. This subset of seeds is registered to the complete reconstruction of the implant in C-arm fluoroscopy. We report results, validated with a leave-one-needle-out approach, both in a phantom (average post-registration seed distance of 2.5 mm) and in three clinical patient datasets (average error: 3.9 mm over 113 seeds).

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages291-298
Number of pages8
Volume14
EditionPt 1
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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