Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm

A. Jain, A. Deguet, I. Iordachita, G. Chintalapani, J. Blevins, Y. Le, E. Armour, C. Burdette, D. Song, G. Fichtinger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Intra-operative guidance in Transrectal Ultrasound (TRUS) guided prostate brachytherapy requires localization of inserted radioactive seeds relative to the prostate. Seeds were reconstructed using a typical C-arm, and exported to a commercial brachytherapy system for dosimetry analysis. Technical obstacles for 3D reconstruction on a nonisocentric C-arm included pose-dependent C-arm calibration; distortion correction; pose estimation of C-arm images; seed reconstruction; and C-arm to TRUS registration. In precision-machined hard phantoms with 40-100 seeds, we correctly reconstructed 99.8% seeds with a mean 3D accuracy of 0.68 mm. In soft tissue phantoms with 45-87 seeds and clinically realistic 15° C-arm motion, we correctly reconstructed 100% seeds with an accuracy of 1.3 mm. The reconstructed 3D seed positions were then registered to the prostate segmented from TRUS. In a Phase-1 clinical trial, so far on 4 patients with 66-84 seeds, we achieved intra-operative monitoring of seed distribution and dosimetry. We optimized the 100% prescribed iso-dose contour by inserting an average of 3.75 additional seeds, making intra-operative dosimetry possible on a typical C-arm, at negligible additional cost to the existing clinical installation.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages9-17
Number of pages9
Volume4792 LNCS
EditionPART 2
StatePublished - 2007
Event10th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2007 - Brisbane, Australia
Duration: Oct 29 2007Nov 2 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume4792 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other10th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2007
CountryAustralia
CityBrisbane
Period10/29/0711/2/07

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

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  • Cite this

    Jain, A., Deguet, A., Iordachita, I., Chintalapani, G., Blevins, J., Le, Y., Armour, E., Burdette, C., Song, D., & Fichtinger, G. (2007). Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (PART 2 ed., Vol. 4792 LNCS, pp. 9-17). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4792 LNCS, No. PART 2).