Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm.

A. Jain, A. Deguet, I. Iordachita, G. Chintalapani, J. Blevins, Y. Le, E. Armour, C. Burdette, Danny Y Song, G. Fichtinger

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Intra-operative guidance in Transrectal Ultrasound (TRUS) guided prostate brachytherapy requires localization of inserted radioactive seeds relative to the prostate. Seeds were reconstructed using a typical C-arm, and exported to a commercial brachytherapy system for dosimetry analysis. Technical obstacles for 3D reconstruction on a non-isocentric C-arm included pose-dependent C-arm calibration; distortion correction; pose estimation of C-arm images; seed reconstruction; and C-arm to TRUS registration. In precision-machined hard phantoms with 40-100 seeds, we correctly reconstructed 99.8% seeds with a mean 3D accuracy of 0.68 mm. In soft tissue phantoms with 45-87 seeds and clinically realistic 15 degrees C-arm motion, we correctly reconstructed 100% seeds with an accuracy of 1.3 mm. The reconstructed 3D seed positions were then registered to the prostate segmented from TRUS. In a Phase-1 clinical trial, so far on 4 patients with 66-84 seeds, we achieved intra-operative monitoring of seed distribution and dosimetry. We optimized the 100% prescribed iso-dose contour by inserting an average of 3.75 additional seeds, making intra-operative dosimetry possible on a typical C-arm, at negligible additional cost to the existing clinical installation.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages9-17
Number of pages9
Volume10
EditionPt 2
StatePublished - 2007

Fingerprint

Brachytherapy
Prostate
Seeds
Clinical Trials, Phase I
Calibration
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jain, A., Deguet, A., Iordachita, I., Chintalapani, G., Blevins, J., Le, Y., ... Fichtinger, G. (2007). Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 2 ed., Vol. 10, pp. 9-17)

Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm. / Jain, A.; Deguet, A.; Iordachita, I.; Chintalapani, G.; Blevins, J.; Le, Y.; Armour, E.; Burdette, C.; Song, Danny Y; Fichtinger, G.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 10 Pt 2. ed. 2007. p. 9-17.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jain, A, Deguet, A, Iordachita, I, Chintalapani, G, Blevins, J, Le, Y, Armour, E, Burdette, C, Song, DY & Fichtinger, G 2007, Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 edn, vol. 10, pp. 9-17.
Jain A, Deguet A, Iordachita I, Chintalapani G, Blevins J, Le Y et al. Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 ed. Vol. 10. 2007. p. 9-17
Jain, A. ; Deguet, A. ; Iordachita, I. ; Chintalapani, G. ; Blevins, J. ; Le, Y. ; Armour, E. ; Burdette, C. ; Song, Danny Y ; Fichtinger, G. / Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 10 Pt 2. ed. 2007. pp. 9-17
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