Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm

A. Jain, A. Deguet, I. Iordachita, G. Chintalapani, J. Blevins, Y. Le, E. Armour, C. Burdette, D. Song, G. Fichtinger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Intra-operative guidance in Transrectal Ultrasound (TRUS) guided prostate brachytherapy requires localization of inserted radioactive seeds relative to the prostate. Seeds were reconstructed using a typical C-arm, and exported to a commercial brachytherapy system for dosimetry analysis. Technical obstacles for 3D reconstruction on a nonisocentric C-arm included pose-dependent C-arm calibration; distortion correction; pose estimation of C-arm images; seed reconstruction; and C-arm to TRUS registration. In precision-machined hard phantoms with 40-100 seeds, we correctly reconstructed 99.8% seeds with a mean 3D accuracy of 0.68 mm. In soft tissue phantoms with 45-87 seeds and clinically realistic 15° C-arm motion, we correctly reconstructed 100% seeds with an accuracy of 1.3 mm. The reconstructed 3D seed positions were then registered to the prostate segmented from TRUS. In a Phase-1 clinical trial, so far on 4 patients with 66-84 seeds, we achieved intra-operative monitoring of seed distribution and dosimetry. We optimized the 100% prescribed iso-dose contour by inserting an average of 3.75 additional seeds, making intra-operative dosimetry possible on a typical C-arm, at negligible additional cost to the existing clinical installation.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2007 - 10th International Conference, Proceedings
PublisherSpringer Verlag
Pages9-17
Number of pages9
EditionPART 2
ISBN (Print)9783540757580
DOIs
StatePublished - 2007
Event10th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2007 - Brisbane, Australia
Duration: Oct 29 2007Nov 2 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume4792 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other10th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2007
CountryAustralia
CityBrisbane
Period10/29/0711/2/07

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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