Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest

Demetris Yannopoulos, Menekhem Zviman, Valeria Castro, Aravindan Kolandaivelu, Ravi Ranjan, Robert F. Wilson, Henry R Halperin

Research output: Contribution to journalArticle

Abstract

BACKGROUND-: We investigated the effects of intra-cardiopulmonary resuscitation (CPR) hypothermia with and without volume loading on return to spontaneous circulation and infarction size in an ischemic model of cardiac arrest. METHODS AND RESULTS-: Using a distal left anterior descending artery occlusion model of cardiac arrest followed by resuscitation with a total of 120 minutes of occlusion and 90 minutes of reperfusion, we randomized 46 pigs into 5 groups and used myocardial staining to define area at risk and myocardial necrosis. Group A had no intervention. Immediately after return of spontaneous circulation, group B received surface cooling with cooling blankets and ice. Group C received intra-CPR 680±23 mL of 28°C 0.9% normal saline via a central venous catheter. Group D received intra-CPR 673±26 mL of 4°C normal saline followed by surface cooling after return of spontaneous circulation. Group E received intra-CPR and hypothermia after return of spontaneous circulation with an endovascular therapeutic hypothermia system placed in the right atrium and set at a target of 32°C. Intra-CPR volume loading with room temperature (group C) or iced saline (group D) significantly (P

Original languageEnglish (US)
Pages (from-to)1426-1435
Number of pages10
JournalCirculation
Volume120
Issue number14
DOIs
StatePublished - Oct 2009

Fingerprint

Cardiopulmonary Resuscitation
Heart Arrest
Hypothermia
Induced Hypothermia
Central Venous Catheters
Ice
Heart Atria
Resuscitation
Infarction
Reperfusion
Necrosis
Swine
Arteries
Staining and Labeling
Temperature

Keywords

  • Cardiopulmonary resuscitation
  • Heart arrest
  • Hypothermia
  • Infarction
  • Resuscitation

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest. / Yannopoulos, Demetris; Zviman, Menekhem; Castro, Valeria; Kolandaivelu, Aravindan; Ranjan, Ravi; Wilson, Robert F.; Halperin, Henry R.

In: Circulation, Vol. 120, No. 14, 10.2009, p. 1426-1435.

Research output: Contribution to journalArticle

Yannopoulos, Demetris ; Zviman, Menekhem ; Castro, Valeria ; Kolandaivelu, Aravindan ; Ranjan, Ravi ; Wilson, Robert F. ; Halperin, Henry R. / Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest. In: Circulation. 2009 ; Vol. 120, No. 14. pp. 1426-1435.
@article{44cbe56641f54a30a311b8c62c55e83e,
title = "Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest",
abstract = "BACKGROUND-: We investigated the effects of intra-cardiopulmonary resuscitation (CPR) hypothermia with and without volume loading on return to spontaneous circulation and infarction size in an ischemic model of cardiac arrest. METHODS AND RESULTS-: Using a distal left anterior descending artery occlusion model of cardiac arrest followed by resuscitation with a total of 120 minutes of occlusion and 90 minutes of reperfusion, we randomized 46 pigs into 5 groups and used myocardial staining to define area at risk and myocardial necrosis. Group A had no intervention. Immediately after return of spontaneous circulation, group B received surface cooling with cooling blankets and ice. Group C received intra-CPR 680±23 mL of 28°C 0.9{\%} normal saline via a central venous catheter. Group D received intra-CPR 673±26 mL of 4°C normal saline followed by surface cooling after return of spontaneous circulation. Group E received intra-CPR and hypothermia after return of spontaneous circulation with an endovascular therapeutic hypothermia system placed in the right atrium and set at a target of 32°C. Intra-CPR volume loading with room temperature (group C) or iced saline (group D) significantly (P",
keywords = "Cardiopulmonary resuscitation, Heart arrest, Hypothermia, Infarction, Resuscitation",
author = "Demetris Yannopoulos and Menekhem Zviman and Valeria Castro and Aravindan Kolandaivelu and Ravi Ranjan and Wilson, {Robert F.} and Halperin, {Henry R}",
year = "2009",
month = "10",
doi = "10.1161/CIRCULATIONAHA.109.848424",
language = "English (US)",
volume = "120",
pages = "1426--1435",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "14",

}

TY - JOUR

T1 - Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest

AU - Yannopoulos, Demetris

AU - Zviman, Menekhem

AU - Castro, Valeria

AU - Kolandaivelu, Aravindan

AU - Ranjan, Ravi

AU - Wilson, Robert F.

AU - Halperin, Henry R

PY - 2009/10

Y1 - 2009/10

N2 - BACKGROUND-: We investigated the effects of intra-cardiopulmonary resuscitation (CPR) hypothermia with and without volume loading on return to spontaneous circulation and infarction size in an ischemic model of cardiac arrest. METHODS AND RESULTS-: Using a distal left anterior descending artery occlusion model of cardiac arrest followed by resuscitation with a total of 120 minutes of occlusion and 90 minutes of reperfusion, we randomized 46 pigs into 5 groups and used myocardial staining to define area at risk and myocardial necrosis. Group A had no intervention. Immediately after return of spontaneous circulation, group B received surface cooling with cooling blankets and ice. Group C received intra-CPR 680±23 mL of 28°C 0.9% normal saline via a central venous catheter. Group D received intra-CPR 673±26 mL of 4°C normal saline followed by surface cooling after return of spontaneous circulation. Group E received intra-CPR and hypothermia after return of spontaneous circulation with an endovascular therapeutic hypothermia system placed in the right atrium and set at a target of 32°C. Intra-CPR volume loading with room temperature (group C) or iced saline (group D) significantly (P

AB - BACKGROUND-: We investigated the effects of intra-cardiopulmonary resuscitation (CPR) hypothermia with and without volume loading on return to spontaneous circulation and infarction size in an ischemic model of cardiac arrest. METHODS AND RESULTS-: Using a distal left anterior descending artery occlusion model of cardiac arrest followed by resuscitation with a total of 120 minutes of occlusion and 90 minutes of reperfusion, we randomized 46 pigs into 5 groups and used myocardial staining to define area at risk and myocardial necrosis. Group A had no intervention. Immediately after return of spontaneous circulation, group B received surface cooling with cooling blankets and ice. Group C received intra-CPR 680±23 mL of 28°C 0.9% normal saline via a central venous catheter. Group D received intra-CPR 673±26 mL of 4°C normal saline followed by surface cooling after return of spontaneous circulation. Group E received intra-CPR and hypothermia after return of spontaneous circulation with an endovascular therapeutic hypothermia system placed in the right atrium and set at a target of 32°C. Intra-CPR volume loading with room temperature (group C) or iced saline (group D) significantly (P

KW - Cardiopulmonary resuscitation

KW - Heart arrest

KW - Hypothermia

KW - Infarction

KW - Resuscitation

UR - http://www.scopus.com/inward/record.url?scp=70349741102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349741102&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.109.848424

DO - 10.1161/CIRCULATIONAHA.109.848424

M3 - Article

C2 - 19770397

AN - SCOPUS:70349741102

VL - 120

SP - 1426

EP - 1435

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 14

ER -