TY - JOUR
T1 - Intra-arterial thrombolytic therapy in peri-coronary angiography ischemic stroke
AU - Zaidat, Osama O.
AU - Slivka, Andy P.
AU - Mohammad, Yousef
AU - Graffagnino, Carmelo
AU - Smith, Tony P.
AU - Enterline, David S.
AU - Christoforidis, Greg A.
AU - Alexander, Michael J.
AU - Landis, Dennis M.D.
AU - Suarez, Jose I.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/5
Y1 - 2005/5
N2 - Background - Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). Methods - A retrospective study was performed involving 3 university hospitals. All peri-CA IAT-treated cases were identified. Patient demographics, stroke severity, angiographic findings, thrombolytic use, modified Rankin Scale (mRS), ICH, and mortality were determined. Results - A total of 21 patients with post-left CA stroke were treated with IAT (mean age 71.8 ± 12.3 years). Arterial occlusion was found in 14 (66.7%) and 7 (33.3%) of the anterior and posterior circulation, respectively. Mean time-to-therapy was 36 ± 12 minutes from the time the neurological deficit was noted. mRS ≤2 occurred in 10 of 21 (48%) patients. Patients with younger age and shorter time-to-IAT had more complete arterial recanalization and clinical recovery. Symptomatic ICH occurred in 3 (14%) cases, and 4 (19%) patients died. Conclusions - Peri-CA IAT appears to be feasible and safe without increased risk of symptomatic ICH and death when compared with the previously reported IAT literature.
AB - Background - Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). Methods - A retrospective study was performed involving 3 university hospitals. All peri-CA IAT-treated cases were identified. Patient demographics, stroke severity, angiographic findings, thrombolytic use, modified Rankin Scale (mRS), ICH, and mortality were determined. Results - A total of 21 patients with post-left CA stroke were treated with IAT (mean age 71.8 ± 12.3 years). Arterial occlusion was found in 14 (66.7%) and 7 (33.3%) of the anterior and posterior circulation, respectively. Mean time-to-therapy was 36 ± 12 minutes from the time the neurological deficit was noted. mRS ≤2 occurred in 10 of 21 (48%) patients. Patients with younger age and shorter time-to-IAT had more complete arterial recanalization and clinical recovery. Symptomatic ICH occurred in 3 (14%) cases, and 4 (19%) patients died. Conclusions - Peri-CA IAT appears to be feasible and safe without increased risk of symptomatic ICH and death when compared with the previously reported IAT literature.
KW - Cardiac catheterization
KW - Cerebrovascular disorders
KW - Stroke
KW - Thrombolysis
KW - Tissue plasminogen activator
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U2 - 10.1161/01.STR.0000162392.44326.ec
DO - 10.1161/01.STR.0000162392.44326.ec
M3 - Article
C2 - 15802636
AN - SCOPUS:20244365511
SN - 0039-2499
VL - 36
SP - 1083
EP - 1084
JO - Stroke
JF - Stroke
IS - 5
ER -