Intra-arterial thrombolytic therapy in peri-coronary angiography ischemic stroke

Osama O. Zaidat, Andy P. Slivka, Yousef Mohammad, Carmelo Graffagnino, Tony P. Smith, David S. Enterline, Greg A. Christoforidis, Michael J. Alexander, Dennis M.D. Landis, Jose I. Suarez

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). Methods - A retrospective study was performed involving 3 university hospitals. All peri-CA IAT-treated cases were identified. Patient demographics, stroke severity, angiographic findings, thrombolytic use, modified Rankin Scale (mRS), ICH, and mortality were determined. Results - A total of 21 patients with post-left CA stroke were treated with IAT (mean age 71.8 ± 12.3 years). Arterial occlusion was found in 14 (66.7%) and 7 (33.3%) of the anterior and posterior circulation, respectively. Mean time-to-therapy was 36 ± 12 minutes from the time the neurological deficit was noted. mRS ≤2 occurred in 10 of 21 (48%) patients. Patients with younger age and shorter time-to-IAT had more complete arterial recanalization and clinical recovery. Symptomatic ICH occurred in 3 (14%) cases, and 4 (19%) patients died. Conclusions - Peri-CA IAT appears to be feasible and safe without increased risk of symptomatic ICH and death when compared with the previously reported IAT literature.

Original languageEnglish (US)
Pages (from-to)1083-1084
Number of pages2
JournalStroke
Volume36
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Cardiac catheterization
  • Cerebrovascular disorders
  • Stroke
  • Thrombolysis
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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