Intra-arterial therapies for liver cancer: assessing tumor response

Yasmin W. Stroehl, Brian S. Letzen, Johanna M M van Breugel, Jean Francois Geschwind, Julius Chapiro

Research output: Contribution to journalReview article

Abstract

Introduction: Intra-arterial therapies (IATs) play an integral role in the management of unresectable hepatocellular carcinoma and liver metastases. The ability to accurately assess tumor response to intra-arterial therapies is crucial for clinical management. Several one- and two-dimensional manual imaging-based response assessment techniques, based both on tumor size or enhancement, have shown to be highly subjective and merely surrogate for the actual tumor as a whole. Areas covered: Given the currently existing literature, we will discuss all available tumor assessment techniques and criteria for liver cancer with a strong emphasis on 3D quantitative imaging biomarkers of tumor response in this review. Expert commentary: The growing role of information technology in medicine has brought about the advent of software-assisted, segmentation-based assessment techniques that address the outstanding issues of a subjective reader and provide for more accurate assessment techniques for the locally treated lesions. Three-dimensional quantitative tumor assessment techniques are superior to one- and two-dimensional measurements. This allows for treatment alterations and more precise targeting, potentially resulting in improved patient outcome.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalExpert Review of Anticancer Therapy
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

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Liver Neoplasms
Neoplasms
Play Therapy
Therapeutics
Aptitude
Tumor Biomarkers
Hepatocellular Carcinoma
Software
Medicine
Neoplasm Metastasis
Technology
Liver

Keywords

  • 3D
  • ADC
  • intraarterial therapy
  • liver cancer
  • qEASL
  • RECIST
  • tumor response
  • tumor staging

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Stroehl, Y. W., Letzen, B. S., van Breugel, J. M. M., Geschwind, J. F., & Chapiro, J. (2017). Intra-arterial therapies for liver cancer: assessing tumor response. Expert Review of Anticancer Therapy, 17(2), 119-127. https://doi.org/10.1080/14737140.2017.1273775

Intra-arterial therapies for liver cancer : assessing tumor response. / Stroehl, Yasmin W.; Letzen, Brian S.; van Breugel, Johanna M M; Geschwind, Jean Francois; Chapiro, Julius.

In: Expert Review of Anticancer Therapy, Vol. 17, No. 2, 01.02.2017, p. 119-127.

Research output: Contribution to journalReview article

Stroehl, YW, Letzen, BS, van Breugel, JMM, Geschwind, JF & Chapiro, J 2017, 'Intra-arterial therapies for liver cancer: assessing tumor response', Expert Review of Anticancer Therapy, vol. 17, no. 2, pp. 119-127. https://doi.org/10.1080/14737140.2017.1273775
Stroehl, Yasmin W. ; Letzen, Brian S. ; van Breugel, Johanna M M ; Geschwind, Jean Francois ; Chapiro, Julius. / Intra-arterial therapies for liver cancer : assessing tumor response. In: Expert Review of Anticancer Therapy. 2017 ; Vol. 17, No. 2. pp. 119-127.
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