Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults

Avishkar Tyagi, Omid Yeganeh, Yakir Levin, Jonathan C. Hooker, Gavin C. Hamilton, Tanya Wolfson, Anthony Gamst, Amir K. Zand, Elhamy Heba, Rohit Loomba, Jeffrey Schwimmer, Michael S. Middleton, Claude B. Sirlin

Research output: Contribution to journalArticle

Abstract

Purpose: Determine intra- and inter-examination repeatability of magnitude-based magnetic resonance imaging (MRI-M), complex-based magnetic resonance imaging (MRI-C), and magnetic resonance spectroscopy (MRS) at 3T for estimating hepatic proton density fat fraction (PDFF), and using MRS as a reference, confirm MRI-M and MRI-C accuracy. Methods: Twenty-nine overweight and obese pediatric (n = 20) and adult (n = 9) subjects (23 male, 6 female) underwent three same-day 3T MR examinations. In each examination MRI-M, MRI-C, and single-voxel MRS were acquired three times. For each MRI acquisition, hepatic PDFF was estimated at the MRS voxel location. Intra- and inter-examination repeatability were assessed by computing standard deviations (SDs) and intra-class correlation coefficients (ICCs). Aggregate SD was computed for each method as the square root of the average of first repeat variances. MRI-M and MRI-C PDFF estimation accuracy was assessed using linear regression with MRS as a reference. Results: For MRI-M, MRI-C, and MRS acquisitions, respectively, mean intra-examination SDs were 0.25%, 0.42%, and 0.49%; mean intra-examination ICCs were 0.999, 0.997, and 0.995; mean inter-examination SDs were 0.42%, 0.45%, and 0.46%; and inter-examination ICCs were 0.995, 0.992, and 0.990. Aggregate SD for each method was <0.9%. Using MRS as a reference, regression slope, intercept, average bias, and R2, respectively, for MRI-M were 0.99%, 1.73%, 1.61%, and 0.986, and for MRI-C were 0.96%, 0.43%, 0.40%, and 0.991. Conclusion: MRI-M, MRI-C, and MRS showed high intra- and inter-examination hepatic PDFF estimation repeatability in overweight and obese subjects. Longitudinal hepatic PDFF change >1.8% (twice the maximum aggregate SD) may represent real change rather than measurement imprecision. Further research is needed to assess whether examinations performed on different days or with different MR technologists affect repeatability of MRS voxel placement and MRS-based PDFF measurements.

Original languageEnglish (US)
Pages (from-to)3070-3077
Number of pages8
JournalAbdominal Imaging
Volume40
Issue number8
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

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Protons
Magnetic Resonance Spectroscopy
Fats
Magnetic Resonance Imaging
Liver
Linear Models
Pediatrics
Research

Keywords

  • Complex-based MRI
  • Hepatic steatosis
  • Inter-examination repeatability
  • Intra-examination repeatability
  • Magnetic resonance spectroscopy
  • Magnitude-based MRI
  • Obesity
  • PDFF
  • Proton density fat fraction
  • Quantitative imaging biomarkers

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. / Tyagi, Avishkar; Yeganeh, Omid; Levin, Yakir; Hooker, Jonathan C.; Hamilton, Gavin C.; Wolfson, Tanya; Gamst, Anthony; Zand, Amir K.; Heba, Elhamy; Loomba, Rohit; Schwimmer, Jeffrey; Middleton, Michael S.; Sirlin, Claude B.

In: Abdominal Imaging, Vol. 40, No. 8, 01.10.2015, p. 3070-3077.

Research output: Contribution to journalArticle

Tyagi, Avishkar ; Yeganeh, Omid ; Levin, Yakir ; Hooker, Jonathan C. ; Hamilton, Gavin C. ; Wolfson, Tanya ; Gamst, Anthony ; Zand, Amir K. ; Heba, Elhamy ; Loomba, Rohit ; Schwimmer, Jeffrey ; Middleton, Michael S. ; Sirlin, Claude B. / Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. In: Abdominal Imaging. 2015 ; Vol. 40, No. 8. pp. 3070-3077.
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title = "Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults",
abstract = "Purpose: Determine intra- and inter-examination repeatability of magnitude-based magnetic resonance imaging (MRI-M), complex-based magnetic resonance imaging (MRI-C), and magnetic resonance spectroscopy (MRS) at 3T for estimating hepatic proton density fat fraction (PDFF), and using MRS as a reference, confirm MRI-M and MRI-C accuracy. Methods: Twenty-nine overweight and obese pediatric (n = 20) and adult (n = 9) subjects (23 male, 6 female) underwent three same-day 3T MR examinations. In each examination MRI-M, MRI-C, and single-voxel MRS were acquired three times. For each MRI acquisition, hepatic PDFF was estimated at the MRS voxel location. Intra- and inter-examination repeatability were assessed by computing standard deviations (SDs) and intra-class correlation coefficients (ICCs). Aggregate SD was computed for each method as the square root of the average of first repeat variances. MRI-M and MRI-C PDFF estimation accuracy was assessed using linear regression with MRS as a reference. Results: For MRI-M, MRI-C, and MRS acquisitions, respectively, mean intra-examination SDs were 0.25{\%}, 0.42{\%}, and 0.49{\%}; mean intra-examination ICCs were 0.999, 0.997, and 0.995; mean inter-examination SDs were 0.42{\%}, 0.45{\%}, and 0.46{\%}; and inter-examination ICCs were 0.995, 0.992, and 0.990. Aggregate SD for each method was <0.9{\%}. Using MRS as a reference, regression slope, intercept, average bias, and R2, respectively, for MRI-M were 0.99{\%}, 1.73{\%}, 1.61{\%}, and 0.986, and for MRI-C were 0.96{\%}, 0.43{\%}, 0.40{\%}, and 0.991. Conclusion: MRI-M, MRI-C, and MRS showed high intra- and inter-examination hepatic PDFF estimation repeatability in overweight and obese subjects. Longitudinal hepatic PDFF change >1.8{\%} (twice the maximum aggregate SD) may represent real change rather than measurement imprecision. Further research is needed to assess whether examinations performed on different days or with different MR technologists affect repeatability of MRS voxel placement and MRS-based PDFF measurements.",
keywords = "Complex-based MRI, Hepatic steatosis, Inter-examination repeatability, Intra-examination repeatability, Magnetic resonance spectroscopy, Magnitude-based MRI, Obesity, PDFF, Proton density fat fraction, Quantitative imaging biomarkers",
author = "Avishkar Tyagi and Omid Yeganeh and Yakir Levin and Hooker, {Jonathan C.} and Hamilton, {Gavin C.} and Tanya Wolfson and Anthony Gamst and Zand, {Amir K.} and Elhamy Heba and Rohit Loomba and Jeffrey Schwimmer and Middleton, {Michael S.} and Sirlin, {Claude B.}",
year = "2015",
month = "10",
day = "1",
doi = "10.1007/s00261-015-0542-5",
language = "English (US)",
volume = "40",
pages = "3070--3077",
journal = "Abdominal Imaging",
issn = "0942-8925",
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}

TY - JOUR

T1 - Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults

AU - Tyagi, Avishkar

AU - Yeganeh, Omid

AU - Levin, Yakir

AU - Hooker, Jonathan C.

AU - Hamilton, Gavin C.

AU - Wolfson, Tanya

AU - Gamst, Anthony

AU - Zand, Amir K.

AU - Heba, Elhamy

AU - Loomba, Rohit

AU - Schwimmer, Jeffrey

AU - Middleton, Michael S.

AU - Sirlin, Claude B.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Purpose: Determine intra- and inter-examination repeatability of magnitude-based magnetic resonance imaging (MRI-M), complex-based magnetic resonance imaging (MRI-C), and magnetic resonance spectroscopy (MRS) at 3T for estimating hepatic proton density fat fraction (PDFF), and using MRS as a reference, confirm MRI-M and MRI-C accuracy. Methods: Twenty-nine overweight and obese pediatric (n = 20) and adult (n = 9) subjects (23 male, 6 female) underwent three same-day 3T MR examinations. In each examination MRI-M, MRI-C, and single-voxel MRS were acquired three times. For each MRI acquisition, hepatic PDFF was estimated at the MRS voxel location. Intra- and inter-examination repeatability were assessed by computing standard deviations (SDs) and intra-class correlation coefficients (ICCs). Aggregate SD was computed for each method as the square root of the average of first repeat variances. MRI-M and MRI-C PDFF estimation accuracy was assessed using linear regression with MRS as a reference. Results: For MRI-M, MRI-C, and MRS acquisitions, respectively, mean intra-examination SDs were 0.25%, 0.42%, and 0.49%; mean intra-examination ICCs were 0.999, 0.997, and 0.995; mean inter-examination SDs were 0.42%, 0.45%, and 0.46%; and inter-examination ICCs were 0.995, 0.992, and 0.990. Aggregate SD for each method was <0.9%. Using MRS as a reference, regression slope, intercept, average bias, and R2, respectively, for MRI-M were 0.99%, 1.73%, 1.61%, and 0.986, and for MRI-C were 0.96%, 0.43%, 0.40%, and 0.991. Conclusion: MRI-M, MRI-C, and MRS showed high intra- and inter-examination hepatic PDFF estimation repeatability in overweight and obese subjects. Longitudinal hepatic PDFF change >1.8% (twice the maximum aggregate SD) may represent real change rather than measurement imprecision. Further research is needed to assess whether examinations performed on different days or with different MR technologists affect repeatability of MRS voxel placement and MRS-based PDFF measurements.

AB - Purpose: Determine intra- and inter-examination repeatability of magnitude-based magnetic resonance imaging (MRI-M), complex-based magnetic resonance imaging (MRI-C), and magnetic resonance spectroscopy (MRS) at 3T for estimating hepatic proton density fat fraction (PDFF), and using MRS as a reference, confirm MRI-M and MRI-C accuracy. Methods: Twenty-nine overweight and obese pediatric (n = 20) and adult (n = 9) subjects (23 male, 6 female) underwent three same-day 3T MR examinations. In each examination MRI-M, MRI-C, and single-voxel MRS were acquired three times. For each MRI acquisition, hepatic PDFF was estimated at the MRS voxel location. Intra- and inter-examination repeatability were assessed by computing standard deviations (SDs) and intra-class correlation coefficients (ICCs). Aggregate SD was computed for each method as the square root of the average of first repeat variances. MRI-M and MRI-C PDFF estimation accuracy was assessed using linear regression with MRS as a reference. Results: For MRI-M, MRI-C, and MRS acquisitions, respectively, mean intra-examination SDs were 0.25%, 0.42%, and 0.49%; mean intra-examination ICCs were 0.999, 0.997, and 0.995; mean inter-examination SDs were 0.42%, 0.45%, and 0.46%; and inter-examination ICCs were 0.995, 0.992, and 0.990. Aggregate SD for each method was <0.9%. Using MRS as a reference, regression slope, intercept, average bias, and R2, respectively, for MRI-M were 0.99%, 1.73%, 1.61%, and 0.986, and for MRI-C were 0.96%, 0.43%, 0.40%, and 0.991. Conclusion: MRI-M, MRI-C, and MRS showed high intra- and inter-examination hepatic PDFF estimation repeatability in overweight and obese subjects. Longitudinal hepatic PDFF change >1.8% (twice the maximum aggregate SD) may represent real change rather than measurement imprecision. Further research is needed to assess whether examinations performed on different days or with different MR technologists affect repeatability of MRS voxel placement and MRS-based PDFF measurements.

KW - Complex-based MRI

KW - Hepatic steatosis

KW - Inter-examination repeatability

KW - Intra-examination repeatability

KW - Magnetic resonance spectroscopy

KW - Magnitude-based MRI

KW - Obesity

KW - PDFF

KW - Proton density fat fraction

KW - Quantitative imaging biomarkers

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U2 - 10.1007/s00261-015-0542-5

DO - 10.1007/s00261-015-0542-5

M3 - Article

C2 - 26350282

AN - SCOPUS:84946482679

VL - 40

SP - 3070

EP - 3077

JO - Abdominal Imaging

JF - Abdominal Imaging

SN - 0942-8925

IS - 8

ER -