TY - JOUR
T1 - Intima-media thickness and regional cérébral blood flow in older adults
AU - Sojkova, Jitka
AU - Najjar, Samer S.
AU - Beason-Held, Lori L.
AU - Metter, E. Jeffrey
AU - Davatzikos, Christos
AU - Kraut, Michael A.
AU - Zonderman, Alan B.
AU - Resnick, Susan M.
PY - 2010/2
Y1 - 2010/2
N2 - Background and Purpose-The relationship between the thickness of the carotid intima (IMT) and brain function remains unclear in those without clinical manifestations of cerebrovascular disease. Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease. Methods-Seventy-three participants in the Baltimore Longitudinal Study of Aging (70.9 years; SD, 7.3) were evaluated with carotid artery ultrasound and resting [O]H2O positron emission tomography. Results-After adjusting for age, gender, and gray and white matter volumes in the regions where IMT is related to regional cérébral blood flow (rCBF), we found that higher IMT was associated with lower rCBF in lingual, inferior occipital, and superior temporal regions. Higher IMT was also associated with higher rCBF in medial frontal gyrus, putamen, and hippocampal-uncal regions (P=0.001). Whereas women had lower IMT (P=0.01) and mean arterial pressure (P=0.05) than men, they showed more robust associations between IMT and rCBF. The relationship between IMT and rCBF was only minimally affected by additional adjustment for mean arterial pressure. Conclusions-IMT is related to patterns of resting rCBF in older adults without clinical manifestations of cerebrovascular disease, suggesting that there are regional differences in CBF that are associated with subclinical vascular disease.
AB - Background and Purpose-The relationship between the thickness of the carotid intima (IMT) and brain function remains unclear in those without clinical manifestations of cerebrovascular disease. Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease. Methods-Seventy-three participants in the Baltimore Longitudinal Study of Aging (70.9 years; SD, 7.3) were evaluated with carotid artery ultrasound and resting [O]H2O positron emission tomography. Results-After adjusting for age, gender, and gray and white matter volumes in the regions where IMT is related to regional cérébral blood flow (rCBF), we found that higher IMT was associated with lower rCBF in lingual, inferior occipital, and superior temporal regions. Higher IMT was also associated with higher rCBF in medial frontal gyrus, putamen, and hippocampal-uncal regions (P=0.001). Whereas women had lower IMT (P=0.01) and mean arterial pressure (P=0.05) than men, they showed more robust associations between IMT and rCBF. The relationship between IMT and rCBF was only minimally affected by additional adjustment for mean arterial pressure. Conclusions-IMT is related to patterns of resting rCBF in older adults without clinical manifestations of cerebrovascular disease, suggesting that there are regional differences in CBF that are associated with subclinical vascular disease.
KW - Aging
KW - Brain
KW - Carotid artery
KW - Common carotid artery
KW - Positron emission tomography
KW - Regional blood flow
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U2 - 10.1161/STROKEAHA.109.566810
DO - 10.1161/STROKEAHA.109.566810
M3 - Article
C2 - 20044526
AN - SCOPUS:77449153561
SN - 0039-2499
VL - 41
SP - 273
EP - 279
JO - Stroke
JF - Stroke
IS - 2
ER -