Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease

Sanjeev Noel, Maria N. Martina-Lingua, Samatha Bandapalle, Jennifer Pluznick, Abdel Rahim A. Hamad, Daniel A. Peterson, Hamid Rabb

Research output: Contribution to journalArticlepeer-review

Abstract

The pathophysiology of acute kidney injury (AKI) involves multiple and overlapping immunological, biochemical, and hemodynamic mechanisms that modulate the effects of both the initial insult and the subsequent repair. Limited but recent experimental data have revealed that the intestinal microbiota significantly affects outcomes in AKI. Additional evidence shows significant changes in the intestinal microbiota in chronic kidney disease patients and in experimental AKI. In this minireview, we discuss the current status of the effect of intestinal microbiota on kidney diseases, the immunomodulatory effects of intestinal microbiota, and the potential mechanisms by which microbiota can modify kidney diseases and vice versa. We also propose future studies to clarify the role of intestinal microbiota in kidney diseases and to explore how the modification of gut microbiota may be a potential therapeutic tool.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalNephron - Clinical Practice
Volume127
Issue number1-4
DOIs
StatePublished - Apr 16 2014
Externally publishedYes

Keywords

  • Acute kidney injury
  • Chronic kidney disease
  • Gut
  • Intestinal microbiota

ASJC Scopus subject areas

  • Nephrology

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