Intestinal electrical stimulation: A novel method for obesity

Jin Song Liu, Xian Qiao, Xiao Hua Hou, Jian De Chen

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the effect of intestinal electrical stimulation (IES) on nutrient absorption in healthy volunteers and its possible mechanism. Methods: Twelve healthy volunteers were enrolled in this 2-session study (real and sham sessions). All volunteers were incubated with a nasal-duodenal feeding tube with 2 ring electrodes into the duodenum and infused with liquid nutrient meal or isotopes labeled non-nutrient meal. The fecal lipid, D-xylose in urine, and intestinal transit time were measured respectively. Real or sham IES was applied and symptoms were scored during the infusion. Results: The lipid and D-xylose absorption was significantly lower in the IES group than in the control group (P < 0.05). The intestinal transit rime was (39 ± 17) minutes in the control session and reduced to (28±10) minutes in the IES session (P < 0.05). Diarrhea was reported in one subject in the control group but in six subjects in the IES group (P < 0.05). Conclusion: IES can decrease the absorption of lipid and carbohydrates and may induce diarrhea, and thus may be an effective therapy for obesity.

Original languageEnglish (US)
Pages (from-to)148-151
Number of pages4
JournalChinese Journal of Clinical Nutrition
Issue number3
StatePublished - Jun 2007
Externally publishedYes


  • Electrical stimulation
  • Intestinal
  • Obesity

ASJC Scopus subject areas

  • Nutrition and Dietetics


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