Objective: To investigate the effect of intestinal electrical stimulation (IES) on nutrient absorption in healthy volunteers and its possible mechanism. Methods: Twelve healthy volunteers were enrolled in this 2-session study (real and sham sessions). All volunteers were incubated with a nasal-duodenal feeding tube with 2 ring electrodes into the duodenum and infused with liquid nutrient meal or isotopes labeled non-nutrient meal. The fecal lipid, D-xylose in urine, and intestinal transit time were measured respectively. Real or sham IES was applied and symptoms were scored during the infusion. Results: The lipid and D-xylose absorption was significantly lower in the IES group than in the control group (P < 0.05). The intestinal transit rime was (39 ± 17) minutes in the control session and reduced to (28±10) minutes in the IES session (P < 0.05). Diarrhea was reported in one subject in the control group but in six subjects in the IES group (P < 0.05). Conclusion: IES can decrease the absorption of lipid and carbohydrates and may induce diarrhea, and thus may be an effective therapy for obesity.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Journal of Clinical Nutrition|
|State||Published - Jun 1 2007|
- Electrical stimulation
ASJC Scopus subject areas
- Nutrition and Dietetics