INTESTINAL ANTIBODY RESPONSES AFTER IMMUNISATION WITH CHOLERA B SUBUNIT

A. M. Svennerholm, J. Holmgren, David Allen Sack, P. K. Bardhan

Research output: Contribution to journalArticle

Abstract

In about 80% of Bangladeshi volunteers a single oral or intramuscular immunisation with a new cholera toxoid immunogen (B subunit) gave rise to a local intestinal secretory immunoglobulin A (IgA) antitoxin response as measured in intestinal-lavage fluid by enzyme-linked immunosorbent assay methods. The rise in IgA antitoxin titre was similar for both immunisation routes and was comparable to that seen after clinical cholera; however, the response persisted longer after oral than intramuscular immunisation. A second immunisation by either route evoked an antitoxin response which usually closely resembled that seen after the first immunisation.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalThe Lancet
Volume319
Issue number8267
DOIs
StatePublished - Feb 6 1982

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Cholera
Antibody Formation
Immunization
Antitoxins
Secretory Immunoglobulin A
Therapeutic Irrigation
Immunoglobulin A
Volunteers
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Medicine(all)

Cite this

INTESTINAL ANTIBODY RESPONSES AFTER IMMUNISATION WITH CHOLERA B SUBUNIT. / Svennerholm, A. M.; Holmgren, J.; Sack, David Allen; Bardhan, P. K.

In: The Lancet, Vol. 319, No. 8267, 06.02.1982, p. 305-308.

Research output: Contribution to journalArticle

Svennerholm, A. M. ; Holmgren, J. ; Sack, David Allen ; Bardhan, P. K. / INTESTINAL ANTIBODY RESPONSES AFTER IMMUNISATION WITH CHOLERA B SUBUNIT. In: The Lancet. 1982 ; Vol. 319, No. 8267. pp. 305-308.
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