INTESTINAL ANTIBODY RESPONSES AFTER IMMUNISATION WITH CHOLERA B SUBUNIT

A. M. Svennerholm, J. Holmgren, D. A. Sack, P. K. Bardhan

Research output: Contribution to journalArticle

Abstract

In about 80% of Bangladeshi volunteers a single oral or intramuscular immunisation with a new cholera toxoid immunogen (B subunit) gave rise to a local intestinal secretory immunoglobulin A (IgA) antitoxin response as measured in intestinal-lavage fluid by enzyme-linked immunosorbent assay methods. The rise in IgA antitoxin titre was similar for both immunisation routes and was comparable to that seen after clinical cholera; however, the response persisted longer after oral than intramuscular immunisation. A second immunisation by either route evoked an antitoxin response which usually closely resembled that seen after the first immunisation.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalThe Lancet
Volume319
Issue number8267
DOIs
StatePublished - Feb 6 1982

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ASJC Scopus subject areas

  • Medicine(all)

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