Abstract
In about 80% of Bangladeshi volunteers a single oral or intramuscular immunisation with a new cholera toxoid immunogen (B subunit) gave rise to a local intestinal secretory immunoglobulin A (IgA) antitoxin response as measured in intestinal-lavage fluid by enzyme-linked immunosorbent assay methods. The rise in IgA antitoxin titre was similar for both immunisation routes and was comparable to that seen after clinical cholera; however, the response persisted longer after oral than intramuscular immunisation. A second immunisation by either route evoked an antitoxin response which usually closely resembled that seen after the first immunisation.
Original language | English (US) |
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Pages (from-to) | 305-308 |
Number of pages | 4 |
Journal | The Lancet |
Volume | 319 |
Issue number | 8267 |
DOIs | |
State | Published - Feb 6 1982 |
ASJC Scopus subject areas
- General Medicine