Intestinal and pancreatic metaplasia at the esophagogastric junction in patients without Barrett's esophagus

Wojciech Polkowski, J. Jan B Van Lanschot, Fiebo J W Ten Kate, Titia M. Rolf, Mirjam Polak, Guido N J Tytgat, Huug Obertop, G. Johan A Offerhaus

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: A distinctive type of columnar epithelium with intestinal metaplasia is considered diagnostic for Barrett's esophagus. The neoplastic potential of pancreatic metaplasia at the esophagogastric junction is unknown. The aims of the present study were: 1) to characterize both forms of metaplasia at the esophagogastric junction, and to estimate their prevalence; 2) to investigate c-erbB-2 expression and K-ras mutations in pancreatic metaplasia; and 3) to study the relationship between metaplasia, inflammatory changes in the cardiac mucosa, and presence of H. pylori. METHODS: A total of 76 esophagogastrectomy specimens of patients with a normally located squamocolumnar junction, were investigated immunohistochemically. K-ras mutations were evaluated using PCR. RESULTS: Intestinal metaplasia in the cardia was found in 12% of patients: six complete-type, and three incomplete- type. Pancreatic metaplasia was demonstrated in 14% of patients, and neither c-erbB-2 expression nor K-ras mutations were found. Intestinal and pancreatic metaplasia were associated with mucosal inflammation. In contrast to generalized gastritis, isolated 'carditis' was not associated with H. pylori infection. CONCLUSIONS: When intestinal metaplasia occurs in a biopsy from the esophagogastric junction, it is not necessarily a marker for Barrett's esophagus. No indication was found that pancreatic metaplasia has neoplastic potential. Both forms of metaplasia reflect mucosal inflammation. Carditis may be a distinct inflammatory condition of the gastric mucosa that is not related to H. pylori infection. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)617-625
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume95
Issue number3
DOIs
StatePublished - Mar 2000
Externally publishedYes

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Esophagogastric Junction
Barrett Esophagus
Metaplasia
Pylorus
Myocarditis
Mutation
Inflammation
Cardia
Gastritis
Gastroenterology
Intestinal Mucosa
Gastric Mucosa
Infection
Mucous Membrane

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Polkowski, W., Van Lanschot, J. J. B., Ten Kate, F. J. W., Rolf, T. M., Polak, M., Tytgat, G. N. J., ... Offerhaus, G. J. A. (2000). Intestinal and pancreatic metaplasia at the esophagogastric junction in patients without Barrett's esophagus. American Journal of Gastroenterology, 95(3), 617-625. https://doi.org/10.1016/S0002-9270(99)00892-8

Intestinal and pancreatic metaplasia at the esophagogastric junction in patients without Barrett's esophagus. / Polkowski, Wojciech; Van Lanschot, J. Jan B; Ten Kate, Fiebo J W; Rolf, Titia M.; Polak, Mirjam; Tytgat, Guido N J; Obertop, Huug; Offerhaus, G. Johan A.

In: American Journal of Gastroenterology, Vol. 95, No. 3, 03.2000, p. 617-625.

Research output: Contribution to journalArticle

Polkowski, W, Van Lanschot, JJB, Ten Kate, FJW, Rolf, TM, Polak, M, Tytgat, GNJ, Obertop, H & Offerhaus, GJA 2000, 'Intestinal and pancreatic metaplasia at the esophagogastric junction in patients without Barrett's esophagus', American Journal of Gastroenterology, vol. 95, no. 3, pp. 617-625. https://doi.org/10.1016/S0002-9270(99)00892-8
Polkowski, Wojciech ; Van Lanschot, J. Jan B ; Ten Kate, Fiebo J W ; Rolf, Titia M. ; Polak, Mirjam ; Tytgat, Guido N J ; Obertop, Huug ; Offerhaus, G. Johan A. / Intestinal and pancreatic metaplasia at the esophagogastric junction in patients without Barrett's esophagus. In: American Journal of Gastroenterology. 2000 ; Vol. 95, No. 3. pp. 617-625.
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abstract = "OBJECTIVES: A distinctive type of columnar epithelium with intestinal metaplasia is considered diagnostic for Barrett's esophagus. The neoplastic potential of pancreatic metaplasia at the esophagogastric junction is unknown. The aims of the present study were: 1) to characterize both forms of metaplasia at the esophagogastric junction, and to estimate their prevalence; 2) to investigate c-erbB-2 expression and K-ras mutations in pancreatic metaplasia; and 3) to study the relationship between metaplasia, inflammatory changes in the cardiac mucosa, and presence of H. pylori. METHODS: A total of 76 esophagogastrectomy specimens of patients with a normally located squamocolumnar junction, were investigated immunohistochemically. K-ras mutations were evaluated using PCR. RESULTS: Intestinal metaplasia in the cardia was found in 12{\%} of patients: six complete-type, and three incomplete- type. Pancreatic metaplasia was demonstrated in 14{\%} of patients, and neither c-erbB-2 expression nor K-ras mutations were found. Intestinal and pancreatic metaplasia were associated with mucosal inflammation. In contrast to generalized gastritis, isolated 'carditis' was not associated with H. pylori infection. CONCLUSIONS: When intestinal metaplasia occurs in a biopsy from the esophagogastric junction, it is not necessarily a marker for Barrett's esophagus. No indication was found that pancreatic metaplasia has neoplastic potential. Both forms of metaplasia reflect mucosal inflammation. Carditis may be a distinct inflammatory condition of the gastric mucosa that is not related to H. pylori infection. (C) 2000 by Am. Coll. of Gastroenterology.",
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AU - Van Lanschot, J. Jan B

AU - Ten Kate, Fiebo J W

AU - Rolf, Titia M.

AU - Polak, Mirjam

AU - Tytgat, Guido N J

AU - Obertop, Huug

AU - Offerhaus, G. Johan A

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N2 - OBJECTIVES: A distinctive type of columnar epithelium with intestinal metaplasia is considered diagnostic for Barrett's esophagus. The neoplastic potential of pancreatic metaplasia at the esophagogastric junction is unknown. The aims of the present study were: 1) to characterize both forms of metaplasia at the esophagogastric junction, and to estimate their prevalence; 2) to investigate c-erbB-2 expression and K-ras mutations in pancreatic metaplasia; and 3) to study the relationship between metaplasia, inflammatory changes in the cardiac mucosa, and presence of H. pylori. METHODS: A total of 76 esophagogastrectomy specimens of patients with a normally located squamocolumnar junction, were investigated immunohistochemically. K-ras mutations were evaluated using PCR. RESULTS: Intestinal metaplasia in the cardia was found in 12% of patients: six complete-type, and three incomplete- type. Pancreatic metaplasia was demonstrated in 14% of patients, and neither c-erbB-2 expression nor K-ras mutations were found. Intestinal and pancreatic metaplasia were associated with mucosal inflammation. In contrast to generalized gastritis, isolated 'carditis' was not associated with H. pylori infection. CONCLUSIONS: When intestinal metaplasia occurs in a biopsy from the esophagogastric junction, it is not necessarily a marker for Barrett's esophagus. No indication was found that pancreatic metaplasia has neoplastic potential. Both forms of metaplasia reflect mucosal inflammation. Carditis may be a distinct inflammatory condition of the gastric mucosa that is not related to H. pylori infection. (C) 2000 by Am. Coll. of Gastroenterology.

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