TY - JOUR
T1 - Interviewer versus self-administered health-related quality of life questionnaires - Does it matter?
AU - Puhan, Milo A.
AU - Ahuja, Alka
AU - Van Natta, Mark L.
AU - Ackatz, Lori E.
AU - Meinert, Curtis
N1 - Funding Information:
University of California, San Francisco: Jacque Duncan, MD (Director); Fermin Ballesteros, Jr.; Robert Bhisitkul, MD, PhD; Debra Brown; David Clay; Michael Deiner; Donald Eubank; Mark Jacobson, MD; Mary Lew, COT; Todd Margolis, MD, PhD. Former Members: Judith Aberg, MD; Jacqueline Hoffman; Alexander Irvine, MD; James Larson; Jody Lawrence, MD; Michael Narahara; Monique Trinidad. University of North Carolina, Chapel Hill: Travis A. Meredith, MD (Director); Sandy Barnhart; Debra Cantrell; Seema Garg, MD, PhD; Elizabeth Hartnett, MD; Maurice B. Landers, MD; Sarah Moyer; David Wohl, MD;. Former Members: Stephanie Betran; Kelly DeBoer; David Eifrig, MD; John Foley, MD; Angela Jeffries; Jan Kylstra, MD; Barbara Longmire; Sharon Myers; Fatima N’Dure, COA; Kean T. Oh, MD; Jeremy Pantell; Susan Pedersen, RN; Cadmus Rich, MD; Cecilia A. Sotelo, RN; Charles van der Horst, MD; Samir Wadhvania. University of Pennsylvania Medical Center, Philadelphia, PA: Charles W. Nichols, MD (Director); Mark Bardsley, BSN; Cheryl C. Devine; Jay Kostman, MD; Albert Maguire, MD; William Nyberg; Leslie Smith, RN. Former Members: Chris Helker, RN; RobRoy MacGregor, MD; Karen McGibney, RN; Keith Mickelberg, RN. University of Southern California, Los Angeles, CA: Former Members: Jennifer I. Lim, MD (Director); Rizwan Bhatti, MD; John Canzano, MD; Thomas S. Chang, MD; Alexander Charonis, MD; Lawrence Chong, MD; Robert Equi, MD; Amani Fawzi, MD; Christina Flaxel, MD; Jesus Garcia; Todd Klesert, MD; Francoise Kramer, MD; Lori Levin, MPH; Tracy Nichols, COA, CRA; Christopher Pelzek, MD; Margaret Podilla, BS; Len Richine; Danny Romo, COA; Srinivas Sadda, MD; Richard Scartozzi, MD; Robert See, MD; Kevin Shiramizu, MD; Mark Thomas; A. Frances Walonker, CO, MPH; Alexander Walsh, MD; Ziquiang Wu, MD. University of South Florida, Tampa, FL: Peter Reed Pavan, MD (Director); JoAnn Leto, COT; Brian Madow, MD; Richard Oehler, MD; Nandesh Patel, MD; Wyatt Saxon; Susan Sherouse, COT. Former Members: Andrew Burrows, MD; Steve Carlton; Burton Goldstein, MD; Sandra Gompf, MD; Bonnie Hernandez, COT; Mohan Iyer, MD; Patrick Kelty, MD; Amy Kramer, COT; Sharon Millard, RN, COT; Jeffrey Nadler, MD; Scott E. Paulter, MD; Jennifer Tordilla-Wadia, MD; Nancy Walker, COA. University of Texas Medical Branch, Galveston, TX: Former Members: Garvin Davis, MD (Director); Robert Blem, MD; J. Mike Bourg, VA; John Horna, BS; Craig Kelso; Zbigniew Krason, BS; Helen K. Li, MD; Lan-Chi Nguyen, COMT; Rhonda Nolen, BS, CRC; Michelle Onarato, MD; David Paar, MD; Steven Rivas; Vicky Seitz, COT; Happy Spillar; Sami Uwaydat, MD. Chairman’s Office, Mount Sinai School of Medicine, New York, New York: Douglas A. Jabs, MD, MBA (Study Chairman); Yasmin Hilal, MHS; Melissa Nieves, BA; Karen Pascual, BBA; Jill Slutsky, MPA; Maria Stevens, CM. Former member: Judith C. Southall. Coordinating Center, The Johns Hopkins University Bloomberg School and Public Health: Curtis L. Meinert, PhD (Director); Alka Ahuja, MS; Debra A. Amend-Libercci; Karen L. Collins; Betty J. Collison; Ryan Colvin; John Dodge; Michele Donithan, MHS; Cathleen Ewing; Kevin Frick, PhD; Janet T. Holbrook, MS, MPH, PhD; Milana R. Isaacson, BS; Rosetta M. Jackson; Hope Livingston; Lee McCaffrey, MA; Milo Puhan, MD, PhD; Girlie Reyes; Jacki Smith; Michael Smith; Elizabeth Sugar, PhD; Jennifer E. Thorne, MD, PhD; James A. Tonascia, PhD; Mark L. Van Natta, MHS; Annette Wagoner. Former members: Carley Benham; Gregory Foster; Judith Harle; Adele M. Kaplan Gilpin, JD, PhD; John H. Kempen, MD, PhD; Barbara K. Martin, PhD; Nancy Min, MPH, PhD; Laurel Murrow, MS; Maria J. Oziemkowska, MS, MPH; Wai Ping Ng, BS; Pamela E. Scott, MA; Erica Smothers; Emily West; Claudine Woo, MPH; Albert Wu, MD, MPH; Alice Zong. Fundus Photograph Reading Center, University of Wisconsin: Ronald Danis, MD (Director); Charles Chandler; Sapna Gangaputra, MD, MPH; Gregory Guilfoil; Larry Hubbard, MAT; Jeffrey Joyce; Thomas Pauli; Nancy Robinson; Dennis Thayer; Jeong Won Pak; Grace Zhang. Former members: Michael Altaweel, MD; Jane Armstrong; Matthew D. Davis, MD; Sheri Glaeser; Katrina Hughes; Dolores Hurlburt; Linda Kastorff; Michael Neider, BA; Therese Traut; Marilyn Vanderhoof-Young; Hugh Wabers;. National Eye Institute, Bethesda, MD: Natalie Kurinij, PhD. Officers of the Study: Douglas A. Jabs, MD, MBA (Chair); Ronald Danis, MD; Natalie Kurinij, PhD; Curtis L. Meinert, PhD; Jennifer E. Thorne, MD, PhD. Former Members: Matthew D. Davis, MD; Janet T. Holbrook, MS, MPH, PhD. Steering Committee: Douglas A. Jabs, MD, MBA (Chair); Ronald Danis, MD; James P. Dunn, MD; Gary N. Holland, MD; Milana R. Isaccson, BS; Mark Jacobson, MD; Natalie Kurinij, PhD; Richard Lewis, MD, MS; Kisten D. Nolan, RN, BSN, MPH; Curtis L. Meinert, PhD; William Nyberg; Frank Palella, MD; Jennifer E. Thorne, MD, PhD. Former Members: Adrienne Addessi, MA, RN; Lisa Brune, RN, BSN; Rebecca Clark, MD; Tom Clark, CRA; Janet Davis, MD; Matthew D. Davis, MD; William R. Freeman, MD; Dorothy Friedberg, MD; James Gilman; Janet T. Holbrook, MS, MPH, PhD; John Horna; Larry Hubbard, MAT; Mark Jacobson, MD; Daniel F. Martin, MD; Travis A. Meredith, MD; Annmarie Muñana, RN; Robert Murphy, MD; P. Reed Pavan, MD; Steven Spencer, BA, COMT; Tim Steffens, CRA; Dennis Thayer; Charles van der Horst, MD; Fran Wallach. Policy and Data Monitoring Board: John P. Phair, MD (Chair); Brian P. Conway, MD; Barry R. Davis, MD, PhD; Douglas A. Jabs, MD, MBA; Natalie Kurinij, PhD; Curtis L. Meinert, PhD; David Musch, PhD; Robert B. Nussenblatt, MD; Jennifer E. Thorne, MD, PhD; Richard Whitley, MD. Former Members: B. William Brown, Jr., PhD; Matthew D. Davis, MD; James Grizzle, PhD; Argye Hillis, PhD; Janet T. Holbrook, MS, MPH, PhD; Harmon Smith, PhD; James A. Tonascia, PhD. Visual Function Quality Assurance Committee: Steven Spencer, BA, COMT (Chair); Robert D. Almanzor; Deborah Gibbs, COMT; Milana Isaacson, BS; Mary Lew, COT; Richard Alan Lewis, MD, MS (Advisor);. Former Members: Ferman Ballesteros; Jeff Grijalva, COT; Karen Lopez; Laura G. Neisser, COT; Rosa Paez-Boham, COST. Financial support: LSOCA is supported by cooperative agreements from the National Eye Institute, Bethesda, Maryland, to Mount Sinai School of Medicine (grant no. U10 EY 08052), Johns Hopkins University Bloomberg School of Public Health (grant no. U10 EY 08057), and University of Wisconsin, Madison (grant no. U10 EY 08067). Additional support was provided by the National Center for Research Resources, Bethesda, Maryland, through General Clinical Research Center grants 5MO1 RR 00188 (Baylor College of Medicine), MO1 RR 00052 (Johns Hopkins University School of Medicine), M01 RR00096 (NYU School of Medicine), 5MO1 RR 05096 (Louisiana State University, Tulane, Charity Hospital), 5MO1 RR 00865 (University of California, Los Angeles), 5MO1 RR 05280 (University of Miami), 5M01 RR00046 (University of North Carolina, Chapel Hill), 5MO1 RR 00043 (University of Southern California), and 5MO1 RR 00047 (Weill Medical College of Cornell University). Support also is provided through cooperative agreements U01 AI 27674 (Louisiana State University, Tulane), U01 AI 27660 (University of California, Los Angeles), U01 AI 276670 (University of California, San Diego), U01 AI 27663 (University of California, San Francisco), U01 AI 25858 (University of North Carolina, Chapel Hill), U01 AI 25903 (Washington University at St. Louis), and U01 AI 32783 (University of Pennsylvania) from the National Institutes of Health.
PY - 2011/5/10
Y1 - 2011/5/10
N2 - Background: Patient-reported outcomes are measured in many epidemiologic studies using self- or interviewer-administered questionnaires. While in some studies differences between these administration formats were observed, other studies did not show statistically significant differences important to patients. Since the evidence about the effect of administration format is inconsistent and mainly available from cross-sectional studies our aim was to assess the effects of different administration formats on repeated measurements of patient-reported outcomes in participants with AIDS enrolled in the Longitudinal Study of Ocular Complications of AIDS.Methods: We included participants enrolled in the Longitudinal Study of Ocular Complications in AIDS (LSOCA) who completed the Medical Outcome Study [MOS] -HIV questionnaire, the EuroQol, the Feeling Thermometer and the Visual Function Questionnaire (VFQ) 25 every six months thereafter using self- or interviewer-administration. A large print questionnaire was available for participants with visual impairment. Considering all measurements over time and adjusting for patient and study site characteristics we used linear models to compare HRQL scores (all scores from 0-100) between administration formats. We defined adjusted differences of ≥0.2 standard deviations [SD]) to be quantitatively meaningful.Results: We included 2,261 participants (80.6% males) with a median of 43.1 years of age at enrolment who provided data on 23,420 study visits. The self-administered MOS-HIV, Feeling Thermometer and EuroQol were used in 70% of all visits and the VFQ-25 in 80%. For eight domains of the MOS-HIV differences between the interviewer- and self- administered format were < 0.1 SD. Differences in scores were highest for the social and role function domains but the adjusted differences were still < 0.2 SD. There was no quantitatively meaningful difference between administration formats for EuroQol, Feeling Thermometer and VFQ-25 domain scores. For ocular pain (VFQ-25), we found a statistically significant difference of 3.5 (95% CI 0.2, 6.8), which did, however, not exceed 0.2 SD. For all instruments scores were similar for the large and standard print formats with all adjusted differences < 0.2 SD.Conclusions: Our large study provides evidence that administration formats do not have a meaningful effect on repeated measurements of patient-reported outcomes. As a consequence, longitudinal studies may not need to consider the effect of different administration formats in their analyses.
AB - Background: Patient-reported outcomes are measured in many epidemiologic studies using self- or interviewer-administered questionnaires. While in some studies differences between these administration formats were observed, other studies did not show statistically significant differences important to patients. Since the evidence about the effect of administration format is inconsistent and mainly available from cross-sectional studies our aim was to assess the effects of different administration formats on repeated measurements of patient-reported outcomes in participants with AIDS enrolled in the Longitudinal Study of Ocular Complications of AIDS.Methods: We included participants enrolled in the Longitudinal Study of Ocular Complications in AIDS (LSOCA) who completed the Medical Outcome Study [MOS] -HIV questionnaire, the EuroQol, the Feeling Thermometer and the Visual Function Questionnaire (VFQ) 25 every six months thereafter using self- or interviewer-administration. A large print questionnaire was available for participants with visual impairment. Considering all measurements over time and adjusting for patient and study site characteristics we used linear models to compare HRQL scores (all scores from 0-100) between administration formats. We defined adjusted differences of ≥0.2 standard deviations [SD]) to be quantitatively meaningful.Results: We included 2,261 participants (80.6% males) with a median of 43.1 years of age at enrolment who provided data on 23,420 study visits. The self-administered MOS-HIV, Feeling Thermometer and EuroQol were used in 70% of all visits and the VFQ-25 in 80%. For eight domains of the MOS-HIV differences between the interviewer- and self- administered format were < 0.1 SD. Differences in scores were highest for the social and role function domains but the adjusted differences were still < 0.2 SD. There was no quantitatively meaningful difference between administration formats for EuroQol, Feeling Thermometer and VFQ-25 domain scores. For ocular pain (VFQ-25), we found a statistically significant difference of 3.5 (95% CI 0.2, 6.8), which did, however, not exceed 0.2 SD. For all instruments scores were similar for the large and standard print formats with all adjusted differences < 0.2 SD.Conclusions: Our large study provides evidence that administration formats do not have a meaningful effect on repeated measurements of patient-reported outcomes. As a consequence, longitudinal studies may not need to consider the effect of different administration formats in their analyses.
KW - AID Squality of life
KW - Administration
KW - Questionnaire
UR - http://www.scopus.com/inward/record.url?scp=79955680276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955680276&partnerID=8YFLogxK
U2 - 10.1186/1477-7525-9-30
DO - 10.1186/1477-7525-9-30
M3 - Article
C2 - 21554737
AN - SCOPUS:79955680276
VL - 9
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
SN - 1477-7525
M1 - 30
ER -