Interventions in Parkinson's disease: Role of executive function

Research output: Contribution to journalArticlepeer-review

Abstract

The cortico-striatal network plays a major role in executive functions (EF), and is believed to play a role in the pathophysiology of Parkinson's disease (PD). However, the tools to assess EF are limited. This review assesses the impact of all PD interventions, namely, pharmacotherapy, physical exercise and Deep Brain Stimulation (DBS) surgery on EF. The effect of PD pharmacotherapy varies with the drug class, neuropsychological test used and the affected dopamine receptor family. There appears to be a benefit of aerobic exercise on EF, including judgment and attention. The effect of Deep Brain Stimulation on EF might vary with site of brain stimulation, the neuropsychological test performed and the pre-operative cognitive state. The effect of EF on underlying manifestations and as a factor in the pathway to the motor benefit needs to be better assessed with more accurate tests that focus on motor component of EF.

Original languageEnglish (US)
Pages (from-to)416-427
Number of pages12
JournalFrontiers in Bioscience - Landmark
Volume22
Issue number3
DOIs
StatePublished - Jan 1 2017

Keywords

  • DBS
  • Executive function
  • Neuroepidemiology
  • Parkinson's disease
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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