Interval shifts in basophil measures correlate with disease activity in chronic spontaneous urticaria

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of those affected through symptoms of pruritus and recurrent skin lesions. In active CSU disease, reduced IgE-mediated basophil histamine release (HR) and basopenia are observed. We sought to examine the relationship between interval changes in basophil measures and shifts in patient-reported disease impairment. Simultaneous symptom and basophil evaluations were completed at two sequential study visits, and interval changes in measures were compared between visits for each subject (n = 38). These measures included Skindex-29, current itch and hives scores, total leukocyte histamine content (an indirect measure of blood basophil presence), and basophil HR in response to anti-IgE and formyl-methionine-leucine-phenylalanine. Overall, interval improvements in disease measures in CSU subjects were associated with increased basophil numbers (total leukocyte histamine content) and IgE-mediated HR. This suggests these measures are potential biomarkers for CSU disease improvement and further implicates a role for basophils in CSU.

Original languageEnglish (US)
Pages (from-to)601-603
Number of pages3
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume70
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • basophil
  • urticaria

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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