Interstitial lung disease in newborns

Research output: Contribution to journalReview articlepeer-review

Abstract

The term ‘interstitial lung disease’ (ILD) refers to a group of disorders involving both the airspaces and tissue compartments of the lung, and these disorders are more accurately termed diffuse lung diseases. Although rare, they are associated with significant morbidity and mortality, with the prognosis depending upon the specific diagnosis. The major categories of ILD in children that present in the neonatal period include developmental disorders, growth disorders, surfactant dysfunction disorders, and specific conditions of unknown etiology unique to infancy. Whereas lung histopathology has been the gold standard for the diagnosis of ILD, as many of the disorders have a genetic basis, non-invasive diagnosis is feasible, and characteristic clinical and imaging features may allow for specific diagnosis in some circumstances. The underlying mechanisms, clinical, imaging, and lung pathology features and outcomes of ILD presenting in newborns are reviewed with an emphasis on genetic mechanisms and diagnosis.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalSeminars in Fetal and Neonatal Medicine
Volume22
Issue number4
DOIs
StatePublished - Aug 2017

Keywords

  • Alveolar capillary dysplasia
  • Genetic basis of disease
  • Lung development
  • Mutation
  • Neuroendocrine cell hyperplasia of infancy
  • Surfactant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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