Interstitial lung disease in idiopathic inflammatory myopathy

Lesley Ann Saketkoo, Dana P. Ascherman, Vincent Cottin, Lisa Christopher-Stine, Sonye Danoff, Chester V. Oddis

Research output: Contribution to journalArticle

Abstract

The lung is one of the most common extra-muscular targets in idiopathic inflammatory myopathies (IIM) and interstitial lung disease (ILD) is a prevalent and often devastating manifestation of IIM. IIM-associated ILD (IIM-ILD) contributes to nearly 80% of the mortality in IIM with a reported prevalence of 65% of newly diagnosed IIM cases. Although ILD frequently accompanies clinical and laboratory findings of myositis, overt signs of muscle disease may be absent in the setting of significant lung disease. Understanding the varied scope of presentation of these diseases is essential to providing optimal patient care. This review will provide an in depth examination of ILD in IIM both from a rheumatologic and pulmonary perspective and will discuss the scope of disease, presenting features, genetic associations, pathogenesis, diagnosis, radiographic and histopathologic findings, along with biomarker assessment and a rationale for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)108-119
Number of pages12
JournalCurrent Rheumatology Reviews
Volume6
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Myositis
Interstitial Lung Diseases
Lung
Lung Diseases
Patient Care
Biomarkers
Muscles
Mortality

Keywords

  • Dermatomyositis
  • Interstitial lung disease
  • Myopathy
  • Myositis
  • Polymyositis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Interstitial lung disease in idiopathic inflammatory myopathy. / Saketkoo, Lesley Ann; Ascherman, Dana P.; Cottin, Vincent; Christopher-Stine, Lisa; Danoff, Sonye; Oddis, Chester V.

In: Current Rheumatology Reviews, Vol. 6, No. 2, 2010, p. 108-119.

Research output: Contribution to journalArticle

Saketkoo, Lesley Ann ; Ascherman, Dana P. ; Cottin, Vincent ; Christopher-Stine, Lisa ; Danoff, Sonye ; Oddis, Chester V. / Interstitial lung disease in idiopathic inflammatory myopathy. In: Current Rheumatology Reviews. 2010 ; Vol. 6, No. 2. pp. 108-119.
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