Interstitial fibrosis and collateral ventilation

D. M. Berzon, H. Menkes, Arthur M. Dannenberg, A. Gertner, Peter Browne Terry, D. Plump, B. Bromberger-Barnea

Research output: Contribution to journalArticle

Abstract

Interstitial fibrosis may increase resistance to collateral flow (Rcoll) because of decreased lung volume and destruction of collateral channels or it may decrease Rcoll because of emphysematous changes around fibrotic regions. In addition, if interstitial fibrosis involves a small region of lung periphery, inter-dependence from surrounding unaffected lung should produce relatively large changes in volume of the fibrotic region during lung inflation. We studied the effects of interstitial fibrosis on collateral airflow by measuring Rcoll at functional residual capacity (FRC) in nine mongrel dogs before and 28 days after the local instillation of bleomycin into selected lung segments. In six of these dogs Rcoll was also measured at a higher lung volume (transpulmonary pressure = 12 cmH2O above FRC pressure). Rcoll increased in fibrotic lung segments following local treatment with bleomycin. With lung inflation (high transpulmonary pressure) Rcoll fell a similar proportion in fibrotic and nonfibrotic lung regions. These observations suggest that collateral resistance increases in fibrotic segments because lung volume decreases or because collateral pathways are involved directly in the fibrotic process. Compensatory increases in collateral communications do not occur. In addition, pulmonary interdependence does not cause disproportionate increases in volume and decreases in Rcoll of the fibrotic region during lung inflation.

Original languageEnglish (US)
Pages (from-to)300-303
Number of pages4
JournalJournal of Applied Physiology
Volume61
Issue number1
StatePublished - 1986

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Ventilation
Fibrosis
Lung
Economic Inflation
Functional Residual Capacity
Bleomycin
Pressure
Dogs
Communication

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Berzon, D. M., Menkes, H., Dannenberg, A. M., Gertner, A., Terry, P. B., Plump, D., & Bromberger-Barnea, B. (1986). Interstitial fibrosis and collateral ventilation. Journal of Applied Physiology, 61(1), 300-303.

Interstitial fibrosis and collateral ventilation. / Berzon, D. M.; Menkes, H.; Dannenberg, Arthur M.; Gertner, A.; Terry, Peter Browne; Plump, D.; Bromberger-Barnea, B.

In: Journal of Applied Physiology, Vol. 61, No. 1, 1986, p. 300-303.

Research output: Contribution to journalArticle

Berzon, DM, Menkes, H, Dannenberg, AM, Gertner, A, Terry, PB, Plump, D & Bromberger-Barnea, B 1986, 'Interstitial fibrosis and collateral ventilation', Journal of Applied Physiology, vol. 61, no. 1, pp. 300-303.
Berzon DM, Menkes H, Dannenberg AM, Gertner A, Terry PB, Plump D et al. Interstitial fibrosis and collateral ventilation. Journal of Applied Physiology. 1986;61(1):300-303.
Berzon, D. M. ; Menkes, H. ; Dannenberg, Arthur M. ; Gertner, A. ; Terry, Peter Browne ; Plump, D. ; Bromberger-Barnea, B. / Interstitial fibrosis and collateral ventilation. In: Journal of Applied Physiology. 1986 ; Vol. 61, No. 1. pp. 300-303.
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