TY - JOUR
T1 - Interstitial chemotherapy for malignant glioma
T2 - Future prospects in the era of multimodal therapy
AU - Mangraviti, Antonella
AU - Tyler, Betty
AU - Brem, Henry
N1 - Publisher Copyright:
© 2015 Ene1 CI.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The advent of interstitial chemotherapy has significantly increased therapeutic options for patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of chemotherapeutic agents, directly at the site of the brain tumor while bypassing systemic toxicities. Gliadel, a locally implanted polymer that releases the alkylating agent carmustine, given alone and in combination with various other antitumor and resistance modifying therapies, has significantly increased the median survival for patients with malignant glioma. Convection enhanced delivery, a technique used to directly infuse drugs into brain tissue, has shown promise for the delivery of immunotoxins, monoclonal antibodies, and chemotherapeutic agents. Preclinical studies include delivery of chemotherapeutic and immunomodulating agents by polymer and microchips. Interstitial chemotherapy was shown to maximize local efficacy and is an important strategy for the efficacy of any multimodal approach.
AB - The advent of interstitial chemotherapy has significantly increased therapeutic options for patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of chemotherapeutic agents, directly at the site of the brain tumor while bypassing systemic toxicities. Gliadel, a locally implanted polymer that releases the alkylating agent carmustine, given alone and in combination with various other antitumor and resistance modifying therapies, has significantly increased the median survival for patients with malignant glioma. Convection enhanced delivery, a technique used to directly infuse drugs into brain tissue, has shown promise for the delivery of immunotoxins, monoclonal antibodies, and chemotherapeutic agents. Preclinical studies include delivery of chemotherapeutic and immunomodulating agents by polymer and microchips. Interstitial chemotherapy was shown to maximize local efficacy and is an important strategy for the efficacy of any multimodal approach.
KW - Carmustine
KW - Gliadel <sup>®</sup>
KW - Glioblastoma multiforme
KW - Interstitial chemotherapy
KW - Malignant glioma
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U2 - 10.4103/2152-7806.151345
DO - 10.4103/2152-7806.151345
M3 - Article
AN - SCOPUS:84930397190
SN - 2152-7806
VL - 6
SP - S78-S84
JO - Surgical Neurology International
JF - Surgical Neurology International
IS - 2
ER -