Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

Annika Schuhbaeck, Damini Dey, Yuka Otaki, Piotr Slomka, Brian G Kral, Stephan Achenbach, Daniel S. Berman, Elliot K Fishman, Shenghan Lai, Hong Chen Lai

Research output: Contribution to journalArticle

Abstract

Objectives: Quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or regression. Our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volumes using a standardized automated method. Methods: Coronary dual source computed tomography angiography (CTA) was performed twice in 20 consecutive patients with known coronary artery disease within a maximum time difference of 100 days. The total plaque volume (TP), the volume of non-calcified plaque (NCP) and calcified plaque (CP) as well as the maximal remodelling index (RI) were determined using automated software. Results: Mean TP volume was 382.3±236.9 mm3 for the first and 399.0±247.3 mm3 for the second examination (p=0.47). There were also no significant differences for NCP volumes, CP volumes or RI. Interscan correlation of the plaque volumes was very good (Pearson's correlation coefficients: r=0.92, r=0.90 and r=0.96 for TP, NCP and CP volumes, respectively). Conclusions: Automated software is a time-saving method that allows accurate assessment of coronary atherosclerotic plaque volumes in coronary CTA with high reproducibility. With this approach, serial studies appear to be possible. Key Points: • Reproducibility of coronary atherosclerotic plaque volume in coronary CTA is high. • Using automated software facilitates quantitative measurements. • Serial studies to determine progression or regression of coronary plaque are possible.

Original languageEnglish (US)
Pages (from-to)2300-2308
Number of pages9
JournalEuropean Radiology
Volume24
Issue number9
DOIs
StatePublished - 2014

Fingerprint

Cone-Beam Computed Tomography
Coronary Angiography
Software
Atherosclerotic Plaques
Disease Progression
Coronary Artery Disease
Computed Tomography Angiography

Keywords

  • Cardiovascular system
  • Coronary artery disease
  • Imaging
  • Multicentre study
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method. / Schuhbaeck, Annika; Dey, Damini; Otaki, Yuka; Slomka, Piotr; Kral, Brian G; Achenbach, Stephan; Berman, Daniel S.; Fishman, Elliot K; Lai, Shenghan; Lai, Hong Chen.

In: European Radiology, Vol. 24, No. 9, 2014, p. 2300-2308.

Research output: Contribution to journalArticle

Schuhbaeck, Annika ; Dey, Damini ; Otaki, Yuka ; Slomka, Piotr ; Kral, Brian G ; Achenbach, Stephan ; Berman, Daniel S. ; Fishman, Elliot K ; Lai, Shenghan ; Lai, Hong Chen. / Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method. In: European Radiology. 2014 ; Vol. 24, No. 9. pp. 2300-2308.
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abstract = "Objectives: Quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or regression. Our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volumes using a standardized automated method. Methods: Coronary dual source computed tomography angiography (CTA) was performed twice in 20 consecutive patients with known coronary artery disease within a maximum time difference of 100 days. The total plaque volume (TP), the volume of non-calcified plaque (NCP) and calcified plaque (CP) as well as the maximal remodelling index (RI) were determined using automated software. Results: Mean TP volume was 382.3±236.9 mm3 for the first and 399.0±247.3 mm3 for the second examination (p=0.47). There were also no significant differences for NCP volumes, CP volumes or RI. Interscan correlation of the plaque volumes was very good (Pearson's correlation coefficients: r=0.92, r=0.90 and r=0.96 for TP, NCP and CP volumes, respectively). Conclusions: Automated software is a time-saving method that allows accurate assessment of coronary atherosclerotic plaque volumes in coronary CTA with high reproducibility. With this approach, serial studies appear to be possible. Key Points: • Reproducibility of coronary atherosclerotic plaque volume in coronary CTA is high. • Using automated software facilitates quantitative measurements. • Serial studies to determine progression or regression of coronary plaque are possible.",
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AU - Achenbach, Stephan

AU - Berman, Daniel S.

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