Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

Objectives: Quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or regression. Our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volumes using a standardized automated method. Methods: Coronary dual source computed tomography angiography (CTA) was performed twice in 20 consecutive patients with known coronary artery disease within a maximum time difference of 100 days. The total plaque volume (TP), the volume of non-calcified plaque (NCP) and calcified plaque (CP) as well as the maximal remodelling index (RI) were determined using automated software. Results: Mean TP volume was 382.3±236.9 mm³ for the first and 399.0±247.3 mm³ for the second examination (p=0.47). There were also no significant differences for NCP volumes, CP volumes or RI. Interscan correlation of the plaque volumes was very good (Pearson's correlation coefficients: r=0.92, r=0.90 and r=0.96 for TP, NCP and CP volumes, respectively). Conclusions: Automated software is a time-saving method that allows accurate assessment of coronary atherosclerotic plaque volumes in coronary CTA with high reproducibility. With this approach, serial studies appear to be possible. Key Points: • Reproducibility of coronary atherosclerotic plaque volume in coronary CTA is high. • Using automated software facilitates quantitative measurements. • Serial studies to determine progression or regression of coronary plaque are possible.